Moving Forward with Metronomic Chemotherapy: Meeting Report of the 2nd International Workshop on Metronomic and Anti-Angiogenic Chemotherapy in Paediatric Oncology

被引:27
作者
Pasquier, Eddy [1 ]
Kieran, Mark W. [2 ,3 ]
Sterba, Jaroslav [4 ]
Shaked, Yuval [5 ]
Baruchel, Sylvain [6 ]
Oberlin, Odile [7 ]
Kivivuori, Maria Sanna [8 ]
Peyrl, Andreas [9 ]
Diawarra, Mamouna [10 ]
Casanova, Michaela [11 ]
Zacharoulis, Stergios [12 ]
Vassal, Gilles [13 ]
Berthold, Franck [14 ,15 ]
Verschuur, Arnauld [16 ]
Andre, Nicolas [16 ,17 ,18 ]
机构
[1] Univ New S Wales, Lowy Canc Res Ctr, Childrens Canc Inst Australia, Randwick, NSW, Australia
[2] Childrens Hosp Boston, Boston, MA USA
[3] Dana Farber Canc Inst, Boston, MA 02115 USA
[4] Univ Hosp Brno, Sch Med Brno, Dept Pediat Oncol, Brno, Czech Republic
[5] Technion Israel Inst Technol, Rappaport Fac Med, Haifa, Israel
[6] Hosp Sick Children, Dept Paediat, Div Haematol Oncol, New Agent & Innovat Therapy Program, Toronto, ON M5G 1X8, Canada
[7] Inst Gustave Roussy, Dept Pediat Oncol, Villejuif, France
[8] Univ Helsinki, Childrens Hosp, Helsinki Univ Cent Hosp, Div Hematol Oncol & Stem Cell Transplantat, Helsinki, Finland
[9] Med Univ Vienna, Dept Paediat, Vienna, Austria
[10] Hop Gabriel Toure, Serv Oncol Pediat, Bamako, Mali
[11] Fdn IRCCS Ist Nazl Tumori, Pediat Oncol Unit, Milan, Italy
[12] Royal Marsden NHS Fdn Trust, Dept Paediat, Sutton, Surrey, England
[13] Univ Paris 11, Inst Gustave Roussy, UPRES EA 3535, Villejuif, France
[14] Univ Childrens Hosp, Dept Paediat Oncol, Cologne, Germany
[15] Ctr Mol Med Cologne, Cologne, Germany
[16] Hop Enfants La Timone, Serv Hematol & Oncol Pediat, F-13885 Marseille 5, France
[17] Univ Aix Marseille, INSERM, UMR 911, Ctr Rech Oncol Biol & Oncopharmacol CRO2, Marseille, France
[18] Metron Global Hlth Initiat, Marseille, France
关键词
ENDOTHELIAL PROGENITOR CELLS; SOLID TUMORS; ORAL ETOPOSIDE; BRAIN-TUMORS; ANTIANGIOGENIC THERAPY; DOSE CYCLOPHOSPHAMIDE; BREAST-CANCER; CHILDREN; RECURRENT; FUTURE;
D O I
10.1593/tlo.11124
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Metronomic chemotherapy, which is defined by the frequent, repetitive administration of chemotherapeutic drugs at relatively low doses, and without prolonged drug-free break, is an emerging strategy to fight cancer. Initially thought to act by targeting tumor angiogenesis, additional mechanisms have been recently unveiled, and metronomic chemotherapy is now considered to represent a form of multitargeted therapy. Despite representing a genuine alternative for advanced and/or high-risk cancer therapy, the development of metronomic approaches in pediatric oncology still in the early stage. The few numbers of large-scale state-of-the-art clinical trials, issues regarding terminology and the limited understanding of the complex and intertwined mechanisms of action of metronomic treatments have limited progress in this important field of research. On March 18 and 19, 2010, the 2nd International Workshop on Metronomic and Anti-Angiogenic Chemotherapy in Paediatric Oncology was held in Marseille, France, and brought together clinicians, basic scientists, physician-scientists, trainees, and students from all around the world. The main aim of this international meeting was to provide a unique forum to 1) reflect on the major advances that have been made in this field of research since its creation, 2) communicate results from the most recent clinical trials and preclinical studies, 3) discuss the current and future challenges of the field, and 4) set forth a solid framework for future collaborative biologic and clinical studies. The present report documents the main preclinical and clinical data that were presented in the keynote and best abstract sessions and delivers the key messages from the meeting.
引用
收藏
页码:189 / 197
页数:9
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