In-Vitro Degradation and Biological Properties of Poly(Lactide-co-Glycolide-co-ε-Caprolactone)/Ethanediamine Modified Poly(Lactide-co-Glycolide) Blend Scaffolds

被引：0

作者：

Fang, Zemei ^{[1
]}

Zhou, Zhihua ^{[1
,2
,3
]}

Wu, Wei ^{[4
]}

Liu, Wenjuan ^{[2
]}

Xie, Hailin ^{[1
]}

Hu, Hongbo ^{[1
]}

Gan, Yan ^{[1
]}

Fang, Jianjun ^{[1
]}

机构：

[1] Hunan Univ Sci & Technol, Sch Chem & Chem Engn, Xiangtan, Peoples R China

[2] Hunan Univ Sci & Technol, Hunan Prov Key Lab Controllable Preparat & Funct A, Xiangtan, Peoples R China

[3] Hunan Univ Sci & Technol, Hunan Prov Coll Key Lab Mol Design & Green Chem, Xiangtan, Peoples R China

[4] Daqing Petrochem Res Inst CNPC, Daqing, Peoples R China

来源：

JOURNAL OF MACROMOLECULAR SCIENCE PART B-PHYSICS | 2022年 / 61卷 / 10-11期

关键词：

biological properties; blend scaffold; ethanediamine modified poly(lactide-co-glycolide); in-vitro degradation; poly(lactide-co-glycolide-co-epsilon-caprolactone); LACTIDE-CO-GLYCOLIDE; MALEATED POLY D; TISSUE; POLY(D; L-LACTIDE-CO-GLYCOLIDE); BEHAVIOR;

D O I：

10.1080/00222348.2022.2160133

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

A degradable blend scaffold composed of poly(D,L-lactide-co-glycolide-co-epsilon-caprolactone) (PLLGC) and ethanediamine modified poly(lactide-co-glycolide) (EMPLGA) was prepared by using a thermally induced phase separation technique. The morphologies of the PLLGC/EMPLGA blend scaffolds were characterized by using scanning electron microscopy (SEM). The in-vitro degradation behaviors and biocompatibility of the individual components and the blend were investigated by using rat L929 cells. The blend scaffolds showed a porous and well interconnected pore structure. The degradation rate sequence of the three scaffolds, the individual components and the blend, was EMPLGA > PLLGC/EMPLGA > PLLGC. The PLLGC/EMPLGA blend scaffold was non-cytotoxic and showed high cell proliferation.

引用

页码：1270 / 1281

页数：12

共 40 条

[1] Biodegradable and biocompatible polymers for tissue engineering application: a review [J].

Asghari, Fatemeh ;

Samiei, Mohammad ;

Adibkia, Khosro ;

Akbarzadeh, Abolfazl ;

Davaran, Soodabeh .

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY, 2017, 45 (02) :185-192

[2] Polyglycolic acid-induced inflammation: Role of hydrolysis and resulting complement activation [J].

Ceonzo, K ;

Gaynor, A ;

Shaffer, L ;

Kojima, K ;

Vacanti, CA ;

Stahl, GL .

TISSUE ENGINEERING, 2006, 12 (02) :301-308

[3] Preparation and Properties of Sodium Alginate/Silk Fibroin Microcarriers [J].

Chen, Ping ;

Zhou, Zhihua ;

Liu, Wenjuan ;

Huang, Tianlong ;

Wu, Wei ;

Yi, Meiling ;

Zhang, Chao ;

He, Xiao ;

Fang, Jianjun .

JOURNAL OF MACROMOLECULAR SCIENCE PART B-PHYSICS, 2022, 61 (4-5) :636-648

[4]

Chen SW, 2016, TISSUE ENG PART C-ME, V22, P189, DOI [10.1089/ten.TEC.2015.0281, 10.1089/ten.tec.2015.0281]

[5] Blends of poly-(ε-caprolactone) and polysaccharides in tissue engineering applications [J].

Ciardelli, G ;

Chiono, V ;

Vozzi, G ;

Pracella, M ;

Ahluwalia, A ;

Barbani, N ;

Cristallini, C ;

Giusti, P .

BIOMACROMOLECULES, 2005, 6 (04) :1961-1976

[6] Hyaluronic acid based scaffolds for tissue engineering-A review [J].

Collins, Maurice N. ;

Birkinshaw, Colin .

CARBOHYDRATE POLYMERS, 2013, 92 (02) :1262-1279

[7] Synthesis, characterization, and degradation behaviors of poly(D,L-lactide-co-glycolide) modified by maleic anhydride and ethanediamine [J].

Cui, Jiale ;

Zhou, Zhihua ;

Yang, Yun ;

Liu, Wenjuan ;

Zhao, Yunfei ;

Peng, Cheng ;

Huang, Tianlong ;

Zhou, Hu ;

Liu, Lihua ;

Zhang, Qiao .

INTERNATIONAL JOURNAL OF POLYMER ANALYSIS AND CHARACTERIZATION, 2017, 22 (07) :575-586

[8]

Dwivedi Ruby, 2020, J Oral Biol Craniofac Res, V10, P381, DOI 10.1016/j.jobcr.2019.10.003

[9] An Overview of Poly(lactic-co-glycolic) Acid (PLGA)-Based Biomaterials for Bone Tissue Engineering [J].

Gentile, Piergiorgio ;

Chiono, Valeria ;

Carmagnola, Irene ;

Hatton, Paul V. .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2014, 15 (03) :3640-3659

[10] Characterization of printed PLA scaffolds for bone tissue engineering [J].

Gremare, Agathe ;

Guduric, Vera ;

Bareille, Reine ;

Heroguez, Valerie ;

Latour, Simon ;

L'heureux, Nicolas ;

Fricain, Jean-Christophe ;

Catros, Sylvain ;

Le Nihouannen, Damien .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2018, 106 (04) :887-894

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