A 64-year-old man with chronic obstructive pulmonary disease and an atypical rash

被引：1

作者：

Craig, Ethan T. ^{[2
]}

Banta, Erin ^{[3
]}

Craig, Timothy J. ^{[1
]}

机构：

[1] Penn State Univ, Dept Med & Pediat, Hershey, PA 17033 USA

[2] Penn State Univ, Penn State Coll Med, Hershey, PA 17033 USA

[3] Penn State Univ, Sect Allergy Asthma & Immunol, Hershey, PA 17033 USA

来源：

ALLERGY AND ASTHMA PROCEEDINGS | 2011年 / 32卷 / 04期

关键词：

ALPHA(1)-ANTITRYPSIN DEFICIENCY; ALPHA-1-ANTITRYPSIN DEFICIENCY; LUNG-FUNCTION; DIAGNOSIS; EMPHYSEMA; FEATURES;

D O I：

10.2500/aap.2011.32.3430

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

A 64-year-old male patient with a 15-year history of chronic obstructive pulmonary disease presented with an atypical rash that was refractory to standard therapy. Pulmonary function tests confirmed an obstructive lung disease. Basic laboratory workup revealed conflicting information, leading to a diagnostic challenge discussed in this article. Ultimately, careful testing did reveal the diagnosis and the patient was treated accordingly. (Allergy Asthma Proc 32:325-328, 2011; doi: 10.2500/aap.2011.32.3430)

引用

页码：325 / 328

页数：4

共 14 条

[1] American Thoracic Society/European Respiratory Society Statement: Standards for the diagnosis and management of individuals with alpha-1 antitrypsin deficiency [J].

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2003, 168 (07) :818-855

[2] Trends in the diagnosis of symptomatic patients with α1-antitrypsin deficiency between 1968 and 2003 [J].

Campos, MA ;

Wanner, A ;

Zhang, GY ;

Sandhaus, RA .

CHEST, 2005, 128 (03) :1179-1186

[3] Kinetic characterisation of alpha-1-antitrypsin F as an inhibitor of human neutrophil elastase [J].

Cook, L ;

Burdon, JGW ;

Brenton, S ;

Knight, KR ;

Janus, ED .

PATHOLOGY, 1996, 28 (03) :242-247

[4] Change in lung function and morbidity from chronic obstructive pulmonary disease in α1-antitrypsin MZ heterozygotes:: A longitudinal study of the general population [J].

Dahl, M ;

Tybjærg-Hansen, A ;

Lange, P ;

Vestbo, J ;

Nordestgaard, BG .

ANNALS OF INTERNAL MEDICINE, 2002, 136 (04) :270-279

[5] α1-Antitrypsin deficiency•2:: Genetic aspects of α1-antitrypsin deficiency:: phenotypes and genetic modifiers of emphysema risk [J].

DeMeo, DL ;

Silverman, EK .

THORAX, 2004, 59 (03) :259-264

[6]

Ioachimescu Octavian C, 2005, COPD, V2, P263

[7]

JANUS ED, 1985, LANCET, V1, P152

[8] Alpha-1 antitrypsin deficiency:: Pathogenesis, clinical presentation, diagnosis, and treatment [J].

Koehnlein, Thomas ;

Welte, Tobias .

AMERICAN JOURNAL OF MEDICINE, 2008, 121 (01) :3-9

[9] Baseline characteristics of enrollees in the national heart, lung and blood institute registry of alpha(1)-antitrypsin deficiency [J].

McElvaney, NG ;

Stoller, JK ;

Buist, AS ;

Prakash, UBS ;

Brantly, ML ;

Schluchter, MD ;

Crystal, RD .

CHEST, 1997, 111 (02) :394-403

[10] Issues in the diagnosis of α1-antitrypsin deficiency [J].

Rachelefsky, Gary ;

Hogarth, D. Kyle .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2008, 121 (04) :833-838

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