Frontotemporal dementia with ubiquitinated neuronal inclusions and visuospatial impairment

被引：5
作者：
Meiner, Z
Newman, JP
Rosenman, H
Soffer, D
Steiner, I
机构：
[1] Hadassah Univ Hosp, Dept Neurol, IL-91120 Jerusalem, Israel
[2] Hadassah Univ Hosp, Agnes Ginges Ctr Human Neurogenet, IL-91120 Jerusalem, Israel
[3] Hadassah Univ Hosp, Dept Pathol, IL-91120 Jerusalem, Israel
[4] Hebrew Univ Jerusalem, Hadassah Med Sch, IL-91120 Jerusalem, Israel
来源：
NEUROLOGY | 2005年 / 65卷 / 03期
关键词：
D O I：
10.1212/01.wnl.0000171347.28558.56
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Dementia with ubiquitinated neuronal inclusions has been described only with frontotemporal dementia (FTD). The authors report a patient with progressive FTD accompanied by prominent impairments in visuospatial cognitive functions. Pathology was characterized by ubiquitin-positive intranuclear and cytoplasmic neuronal inclusions. Cortical pathology was widespread and posteriorly accentuated but spared the hippocampal dentate gyrus.
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页码：478 / 480
页数：3
相关论文
共 10 条
[1]  
BRUN A, 1994, J NEUROL NEUROSUR PS, V57, P416
[2]   Toward a molecular neuropsychiatry of neurodegenerative diseases [J].
Cummings, JL .
ANNALS OF NEUROLOGY, 2003, 54 (02) :147-154
[3]   Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain [J].
DiFiglia, M ;
Sapp, E ;
Chase, KO ;
Davies, SW ;
Bates, GP ;
Vonsattel, JP ;
Aronin, N .
SCIENCE, 1997, 277 (5334) :1990-1993
[4]   Motor neurone disease-inclusion dementia [J].
Jackson, M ;
Lennox, G ;
Lowe, J .
NEURODEGENERATION, 1996, 5 (04) :339-350
[5]   Familial frontotemporal dementia with ubiquitin-positive, tau-negative inclusions [J].
Kertesz, A ;
Kawarai, T ;
Rogaeva, E ;
St George-Hyslop, P ;
Poorkaj, P ;
Bird, TD ;
Munoz, DG .
NEUROLOGY, 2000, 54 (04) :818-827
[6]   PRESENILE-DEMENTIA WITH MOTOR NEURON DISEASE IN JAPAN - CLINICOPATHOLOGICAL REVIEW OF 26 CASES [J].
MITSUYAMA, Y .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1984, 47 (09) :953-959
[7]   UBIQUITIN-POSITIVE INTRANEURONAL INCLUSIONS IN THE EXTRA-MOTOR CORTICES OF PRESENILE-DEMENTIA PATIENTS WITH MOTOR-NEURON DISEASE [J].
OKAMOTO, K ;
MURAKAMI, N ;
KUSAKA, H ;
YOSHIDA, M ;
HASHIZUME, Y ;
NAKAZATO, Y ;
MATSUBARA, E ;
HIRAI, S .
JOURNAL OF NEUROLOGY, 1992, 239 (08) :426-430
[8]   Familial frontotemporal dementia with ubiquitin-positive inclusions is linked to chromosome 17q2l-22 [J].
Rosso, SM ;
Kamphorst, W ;
de Graaf, B ;
Willemsen, R ;
Ravid, R ;
Niermeijer, MF ;
Spillantini, MG ;
Heutink, P ;
van Swieten, JC .
BRAIN, 2001, 124 :1948-1957
[9]   HIPPOCAMPAL AND NEOCORTICAL UBIQUITIN-IMMUNOREACTIVE INCLUSIONS IN AMYOTROPHIC-LATERAL-SCLEROSIS WITH DEMENTIA [J].
WIGHTMAN, G ;
ANDERSON, VER ;
MARTIN, J ;
SWASH, M ;
ANDERTON, BH ;
NEARY, D ;
MANN, D ;
LUTHERT, P ;
LEIGH, PN .
NEUROSCIENCE LETTERS, 1992, 139 (02) :269-274
[10]  
Woulfe J, 2001, ACTA NEUROPATHOL, V102, P94
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