Fabrication of nanoaggregates of poly(ethylene oxide)-b-polymethacrylate by complex formation with chitosan or methylglycolchitosan

被引：15

作者：

Khanal, A ^{[1
]}

Nakashima, Y ^{[1
]}

Li, Y ^{[1
]}

Nakashima, K ^{[1
]}

Kawasaki, N ^{[1
]}

Oishi, Y ^{[1
]}

机构：

[1] Saga Univ, Fac Sci & Engn, Dept Chem, Saga 8408502, Japan

来源：

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS | 2005年 / 260卷 / 1-3期

关键词：

poly(ethylene oxide)-b-polymethacrylate; chitosan; methylglycolchitosan; nanoaggregates; counterions;

D O I：

10.1016/j.colsurfa.2005.03.029

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Nanoaggregate formation of poly(ethylene oxide)-b-polymethacrylate (PEO-b PMA) is induced by chitosan (Ch) or methylglycolchitosan (MGC). The nanoaggregates are basically obtained by electrical charge neutralization of the anionic PMA block of the PEO-b-PMA polymer with cationic Ch or MGC, which results in insolubilization of the PMA block to form the core of the aggregates. Formation of the nanoaggregates was confirmed by dynamic light scattering, fluorescence spectroscopy, atomic force microscopy and zeta-potential measurements. The properties of the nanoaggregates depend upon the concentration of the polymer as well as the concentration of Ch or MGC. The significance of these aggregates is their ability to incorporate ionic species, leading them to potential applications as drug carriers and nanoreactors. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：129 / 135

页数：7

共 38 条

[1] MICELLIZATION IN BLOCK POLYELECTROLYTE SOLUTIONS .2. FLUORESCENCE STUDY OF THE CRITICAL MICELLE CONCENTRATION AS A FUNCTION OF SOLUBLE BLOCK LENGTH AND SALT CONCENTRATION [J].

ASTAFIEVA, I ;

KHOUGAZ, K ;

EISENBERG, A .

MACROMOLECULES, 1995, 28 (21) :7127-7134

[2] CRITICAL MICELLIZATION PHENOMENA IN BLOCK POLYELECTROLYTE SOLUTIONS [J].

ASTAFIEVA, I ;

ZHONG, XF ;

EISENBERG, A .

MACROMOLECULES, 1993, 26 (26) :7339-7352

[3] Self-assembly in mixtures of poly(ethylene oxide)-graft-poly(ethyleneimine) and alkyl sulfates [J].

Bronich, TK ;

Cherry, T ;

Vinogradov, SV ;

Eisenberg, A ;

Kabanov, VA ;

Kabanov, AV .

LANGMUIR, 1998, 14 (21) :6101-6106

[4] Soluble complexes from poly(ethylene oxide)-block-polymethacrylate anions and N-alkylpyridinium cations [J].

Bronich, TK ;

Kabanov, AV ;

Kabanov, VA ;

Yu, K ;

Eisenberg, A .

MACROMOLECULES, 1997, 30 (12) :3519-3525

[5] Effects of block length and structure of surfactant on self-assembly and solution behavior of block ionomer complexes [J].

Bronich, TK ;

Popov, AM ;

Eisenberg, A ;

Kabanov, VA ;

Kabanov, AV .

LANGMUIR, 2000, 16 (02) :481-489

[6] Induced micellization by interaction of poly(2-vinylpyridine)-block-poly(ethylene oxide) with metal compounds.: Micelle characteristics and metal nanoparticle formation [J].

Bronstein, LH ;

Sidorov, SN ;

Valetsky, PM ;

Hartmann, J ;

Cölfen, H ;

Antonietti, M .

LANGMUIR, 1999, 15 (19) :6256-6262

[7] Interaction of metal compounds with 'double-hydrophilic' block copolymers in aqueous medium and metal colloid formation [J].

Bronstein, LM ;

Sidorov, SN ;

Gourkova, AY ;

Valetsky, PM ;

Hartmann, J ;

Breulmann, M ;

Colfen, H ;

Antonietti, M .

INORGANICA CHIMICA ACTA, 1998, 280 (1-2) :348-354

[8]

Cölfen H, 2001, MACROMOL RAPID COMM, V22, P219, DOI 10.1002/1521-3927(20010201)22:4<219::AID-MARC219>3.0.CO

[9]

2-G

[10]

Conti B, 2000, STP PHARMA SCI, V10, P101

← 1 2 3 4 →