Autophagy and Diabetic Encephalopathy: Mechanistic Insights and Potential Therapeutic Implications

被引:22
|
作者
Cheng, Li-zhen [1 ]
Li, Wei [1 ]
Chen, Yi-xin [1 ]
Lin, Yi-jia [1 ]
Miao, Ya [1 ]
机构
[1] Shanghai Jiao Tong Univ, Dept Geriatr, Affiliated Peoples Hosp 6, Shanghai, Peoples R China
来源
AGING AND DISEASE | 2022年 / 13卷 / 02期
关键词
diabetes mellitus; cognitive impairment; diabetic encephalopathy; autophagy; HIPPOCAMPAL SYNAPTIC PLASTICITY; OXIDATIVE STRESS; COGNITIVE IMPAIRMENT; AMYLOID-BETA; SIGNALING PATHWAYS; MOUSE MODEL; VITAMIN-E; TAU; BRAIN; APOPTOSIS;
D O I
10.14336/AD.2021.0823
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Diabetic Encephalopathy (DE) is one of the complications of diabetes mellitus (DM) in the central nervous system. Up to now, the mechanisms of DE are not fully discussed by the field. Autophagy is an intracellular degradation pathway crucial to maintain cellular homeostasis by clearing damaged organelles, pathogens, and unwanted protein aggregates. Increasing evidence has demonstrated that autophagy might play an essential role in DE progress. In this review, we summarize the current evidence on autophagy dysfunction under the condition of DE, and provide novel insights of possibly biological mechanisms linking autophagy impairment to DE, as well as discuss autophagy-targeted therapies as potential treatments for DE
引用
收藏
页码:447 / 457
页数:11
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