Infections with highly pathogenic avian influenza A virus (HPAIV) H5N8 in harbor seals at the German North Sea coast, 2021

被引：44

作者：

Postel, Alexander ^{[1
]}

King, Jacqueline ^{[2
]}

Kaiser, Franziska K. ^{[3
]}

Kennedy, Johanna ^{[1
]}

Lombardo, Mara Sophie ^{[4
]}

Reineking, Wencke ^{[4
]}

de le Roi, Madeleine ^{[4
]}

Harder, Timm ^{[2
]}

Pohlmann, Anne ^{[2
]}

Gerlach, Thomas ^{[3
]}

Rimmelzwaan, Guus ^{[3
]}

Rohner, Simon ^{[5
]}

Striewe, Lotte C. ^{[5
]}

Gross, Stephanie ^{[5
]}

Schick, Luca A. ^{[5
]}

Klink, Jana C. ^{[5
]}

Kramer, Katharina ^{[6
]}

Osterhaus, Albert D. M. E. ^{[3
]}

Beer, Martin ^{[2
]}

Baumgaertner, Wolfgang ^{[4
]}

Siebert, Ursula ^{[5
]}

Becher, Paul ^{[1
]}

机构：

[1] Univ Vet Med, Inst Virol, Hannover, Germany

[2] Friedrich Loeffler Inst, Inst Diagnost Virol, Greifswald, Germany

[3] Univ Vet Med, Res Ctr Emerging Infect & Zoonoses, Hannover, Germany

[4] Univ Vet Med, Inst Pathol, Hannover, Germany

[5] Univ Vet Med, Inst Terr & Aquat Wildlife Res, Hannover, Germany

[6] Landeslab Schleswig Holstein, Neumunster, Germany

来源：

EMERGING MICROBES & INFECTIONS | 2022年 / 11卷 / 01期

关键词：

Influenza virus; HPAIV; avian; seal; mammal; brain; lung; A(H5N8); VIRUS;

D O I：

10.1080/22221751.2022.2043726

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In brain tissue of three harbor seals of the German North Sea coast, high virus loads of highly pathogenic avian influenza virus (HPAIV) H5N8 were detected. Identification of different virus variants indicates high exposure to HPAIV circulating in wild birds, but there is no evidence for H5 specific antibodies in healthy seals. Replication of avian viruses in seals may allow HPAIV to acquire mutations needed to adapt to mammalian hosts as shown by PB2 627K variants detected in these cases.

引用

页码：725 / 729

页数：5

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