The discovery of SYP-10913 and SYP-11277: novel strobilurin acaricides

被引：36

作者：

Chai, Bao-Shan ^{[1
,2
]}

Liu, Chang-Ling ^{[1
,2
]}

Li, Hui-Chao ^{[1
]}

Zhang, Hong ^{[1
]}

Liu, Shao-Wu ^{[1
]}

Huang, Guang ^{[1
]}

Chang, Jun-Biao ^{[2
]}

机构：

[1] Shenyang Res Inst Chem Ind, State Key Lab Discovery & Dev Novel Pesticides, Shenyang 110021, Peoples R China

[2] Zhengzhou Univ, Dept Chem, Zhengzhou 450052, Peoples R China

来源：

PEST MANAGEMENT SCIENCE | 2011年 / 67卷 / 09期

关键词：

strobilurin; pyrimidine; acaricidal activity; intermediate derivatisation method; DESIGN; DERIVATIVES;

D O I：

10.1002/ps.2164

中图分类号：

S3 [农学（农艺学）];

学科分类号：

0901 ;

摘要：

BACKGROUND: As previously reported, methyl (E)-2-[2-(2-phenylamino-6-trifluoromethylpyrimidin-4-yloxymethyl) phenyl]-3-methoxyacrylate has proven to be a new lead with highly acaricidal activity. Following on from this, in an effort to discover new strobilurin analogues with improved activity, a series of substituted pyrimidines were synthesised and bioassayed. RESULTS: All compounds were characterised by H-1 NMR, IR, MS and elemental analysis. Preliminary bioassays demonstrated that some of the title compounds exhibited notable control of Tetranychus cinnabarinus (Boisd.) at 1.25 mg L-1. The relationship between structure and acaricidal activity is discussed. CONCLUSION: Two compounds of particular interest, 6j (SYP-10913) and 6k (SYP-11277), exhibited potent acaricidal activity. The acaricidal potencies of these analogues are higher than that of fluacrypyrim in greenhouse applications, and are comparable with those of commercial acaricides such as spirodiclofen and propargite in field trials. (C) 2011 Society of Chemical Industry

引用

页码：1141 / 1146

页数：6

共 12 条

[1] A method of computing the effectiveness of an insecticide [J].

Abbott, WS .

JOURNAL OF ECONOMIC ENTOMOLOGY, 1925, 18 :265-267

[2] Design, synthesis and acaricidal activity of novel strobilurin derivatives containing pyrimidine moieties [J].

Chai, Bao-Shan ;

Liu, Chang-Ling ;

Li, Hui-Chao ;

He, Xiao-Min ;

Luo, Yan-Mei ;

Huang, Guang ;

Zhang, Hong ;

Chang, Jun-Biao .

PEST MANAGEMENT SCIENCE, 2010, 66 (11) :1208-1214

[3] Design, synthesis and biological activities of new strobilurin derivatives containing substituted pyrazoles [J].

Li, Miao ;

Liu, Chang-Ling ;

Li, Lin ;

Yang, Hao ;

Li, Zhi-Nian ;

Zhang, Hong ;

Li, Zheng-Ming .

PEST MANAGEMENT SCIENCE, 2010, 66 (01) :107-112

[4]

Liu CL, 2007, NAT PROD COMMUN, V2, P845

[5]

LIU CL, 2010, Patent No. 2010073484

[6]

LIU CL, 2006, Patent No. 1869032

[7]

LIU CL, 2005, Patent No. 2005080344

[8]

LIU CL, 2008, HIGH TECHNOL IND, V9, P79

[9]

LIU CL, 2009, FRONTIERS MODERN CHE, P86

[10]

LIU CL, 2005, Patent No. 2006125370

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