MicroRNAs in cancer metastasis and angiogenesis

被引：78

作者：

Lou, Weiyang ^{[1
]}

Liu, Jingxing ^{[2
]}

Gao, Yanjia ^{[3
]}

Zhong, Guansheng ^{[1
]}

Chen, Danni ^{[1
]}

Shen, Jiaying ^{[1
]}

Bao, Chang ^{[1
]}

Xu, Liang ^{[4
]}

Pan, Jie ^{[1
]}

Cheng, Junchi ^{[5
]}

Ding, Bisha ^{[1
]}

Fan, Weimin ^{[1
,6
]}

机构：

[1] Zhejiang Univ, Affiliated Hosp 1,Dept Surg Coll Med,Key Lab Orga, Program Innovat Canc Therapeut,Div Hepatobiliary, Key Lab Combined Multiorgan Transplantat,Minist P, Hangzhou 310003, Zhejiang, Peoples R China

[2] Changxing Peoples Hosp Zhejiang, Dept Intens Care Unit, Huzhou 313100, Zhejiang, Peoples R China

[3] Zhejiang Univ, Dept Anesthesiol, Int Hosp, Shulan Hangzhou Hosp, Hangzhou 310003, Zhejiang, Peoples R China

[4] Zhejiang Univ, Coll Med, Clin Res Ctr, Affiliated Hosp 1, Hangzhou 310003, Zhejiang, Peoples R China

[5] Zhejiang Canc Hosp, Dept Chemotherapy, Hangzhou 310003, Zhejiang, Peoples R China

[6] Med Univ South Carolina, Dept Pathol & Lab Med, Charleston, SC 29425 USA

来源：

ONCOTARGET | 2017年 / 8卷 / 70期

基金：

中国国家自然科学基金;

关键词：

angiogenesis; cancer; microRNAs; metastasis; therapy; EPITHELIAL-MESENCHYMAL TRANSITION; CELL LUNG-CANCER; INHIBITS TUMOR ANGIOGENESIS; NEGATIVE BREAST-CANCER; HEPATOCELLULAR-CARCINOMA; ENDOTHELIAL-CELLS; COLORECTAL-CANCER; GASTRIC-CANCER; DOWN-REGULATION; SUPPRESSES ANGIOGENESIS;

D O I：

10.18632/oncotarget.23115

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancer metastasis is a malignant process by which tumor cells migrate from their primary site of origin to other organs. It is the main cause of poor prognosis in cancer patients. Angiogenesis is the process of generating new blood capillaries from pre-existing vasculature. It plays a vital role in primary tumor growth and distant metastasis. MicroRNAs are small non-coding RNAs involved in regulating normal physiological processes as well as cancer pathogenesis. They suppress gene expression by specifically binding to the 3'-untranslated region (3'-UTR) of their target genes. They can thus act as oncogenes or tumor suppressors depending on the function of their target genes. MicroRNAs have shown great promise for use in anti-metastatic cancer therapy. In this article, we review the roles of various miRNAs in cancer angiogenesis and metastasis and highlight their potential for use in future therapies against metastatic cancer.

引用

页码：115787 / 115802

页数：16

共 161 条

[1] Molecular regulation of angiogenesis and lymphangiogenesis [J].

Adams, Ralf H. ;

Alitalo, Kari .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2007, 8 (06) :464-478

[2] miR-218 Suppresses Nasopharyngeal Cancer Progression through Downregulation of Survivin and the SLIT2-ROBO1 Pathway [J].

Alajez, Nehad M. ;

Lenarduzzi, Michelle ;

Ito, Emma ;

Hui, Angela B. Y. ;

Shi, Wei ;

Bruce, Jeff ;

Yue, Shijun ;

Huang, Shao H. ;

Xu, Wei ;

Waldron, John ;

O'Sullivan, Brian ;

Liu, Fei-Fei .

CANCER RESEARCH, 2011, 71 (06) :2381-2391

[3] The functions of animal microRNAs [J].

Ambros, V .

NATURE, 2004, 431 (7006) :350-355

[4] Overexpression of secretagogin inhibits cell apoptosis and induces chemoresistance in small cell lung cancer under the regulation of miR-494 [J].

Bai, Yifeng ;

Sun, Yanqin ;

Peng, Juan ;

Liao, Hongzhan ;

Gao, Hongyi ;

Guo, Ying ;

Guo, Linlang .

ONCOTARGET, 2014, 5 (17) :7760-7775

[5] MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004) [J].

Bartel, David P. .

CELL, 2007, 131 (04) :11-29

[6] AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients [J].

Batchelor, Tracy T. ;

Sorensen, A. Gregory ;

di Tomaso, Emmanuelle ;

Zhang, Wei-Ting ;

Duda, Dan G. ;

Cohen, Kenneth S. ;

Kozak, Kevin R. ;

Cahill, Daniel P. ;

Chen, Poe-Jou ;

Zhu, Mingwang ;

Ancukiewicz, Marek ;

Mrugala, Maciej M. ;

Plotkin, Scott ;

Drappatz, Jan ;

Louis, David N. ;

Ivy, Percy ;

Scadden, David T. ;

Benner, Thomas ;

Loeffler, Jay S. ;

Wen, Patrick Y. ;

Jain, Rakesh K. .

CANCER CELL, 2007, 11 (01) :83-95

[7] Modes of resistance to anti-angiogenic therapy [J].

Bergers, Gabriele ;

Hanahan, Douglas .

NATURE REVIEWS CANCER, 2008, 8 (08) :592-603

[8] Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies [J].

Bernardi, Rosa ;

Pandolfi, Pier Paolo .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2007, 8 (12) :1006-1016

[9] Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs [J].

Bohnsack, MT ;

Czaplinski, K ;

Görlich, D .

RNA, 2004, 10 (02) :185-191

[10]

BUTLER TP, 1975, CANCER RES, V35, P512

← 1 2 3 4 5 6 7 8 9 10 →