Osteopontin expression in salivary gland carcinomas

被引：3

作者：

Bjorndal, Kristine ^{[1
]}

Larsen, Stine R. ^{[2
]}

Godballe, Christian ^{[1
]}

Krogdahl, Annelise ^{[2
]}

机构：

[1] Odense Univ Hosp, Dept ENT Head & Neck Surg, DK-5000 Odense C, Denmark

[2] Odense Univ Hosp, Dept Pathol, DK-5000 Odense C, Denmark

来源：

JOURNAL OF ORAL PATHOLOGY & MEDICINE | 2011年 / 40卷 / 06期

关键词：

immunohistochemistry; osteopontin; prognostic factors; salivary gland carcinomas; CELL LUNG-CANCER; PROGNOSTIC-SIGNIFICANCE; PROTEIN EXPRESSION; BREAST-CANCER; ASSOCIATION; PROGRESSION; MARKER; HEAD;

D O I：

10.1111/j.1600-0714.2010.00964.x

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

BACKGROUND: In several cancer types, osteopontin (OPN) expression has been correlated with tumor progression and prognosis. Two earlier studies have examined OPN expression in salivary gland carcinomas with contradictory results. METHODS: One hundred and seventy-five patients with a primary salivary gland carcinoma diagnosed from January 1, 1990 to December 31, 2005 were identified in the local pathology register, Odense University Hospital. Criteria as documented by Allred et al. were used to assess OPN immunostaining that was performed on surgical specimens. RESULTS: Osteopontin was expressed in all salivary gland carcinomas. Adenoid cystic carcinomas had the highest mean sum score (7.3) and a significantly higher proportion of carcinomas with high OPN sum score than both mucoepidermoid carcinoma and acinic cell carcinoma. Correlation of OPN expression with known prognostic factors in salivary gland carcinomas was insignificant. CONCLUSIONS: Salivary gland carcinomas express OPN. The expression does not correlate with known prognostic factors. J Oral Pathol Med (2011) 40: 451-455

引用

页码：451 / 455

页数：5

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