Adipose Stem Cells in Regenerative Medicine: Looking Forward

被引：62
作者：
Al-Ghadban, Sara [1 ]
Artiles, Maria [1 ]
Bunnell, Bruce A. [1 ]
机构：
[1] Univ North Texas, Hlth Sci Ctr, Dept Microbiol Immunol & Genet, Ft Worth, TX 76107 USA
来源：
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY | 2022年 / 9卷
关键词：
adipose-derived stem cells (ASCs); regenerative medicine; tissue engineering; scaffolds; microfluidic systems; PLATELET-RICH PLASMA; CARTILAGE REGENERATION; STROMAL CELLS; TISSUE; DIFFERENTIATION; TRANSPLANTATION; SCAFFOLDS; SURVIVAL; THERAPY; OSTEOARTHRITIS;
D O I：
10.3389/fbioe.2021.837464
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Over the last decade, stem cell-based regenerative medicine has progressed to clinical testing and therapeutic applications. The applications range from infusions of autologous and allogeneic stem cells to stem cell-derived products. Adult stem cells from adipose tissue (ASCs) show significant promise in treating autoimmune and neurodegenerative diseases, vascular and metabolic diseases, bone and cartilage regeneration and wound defects. The regenerative capabilities of ASCs in vivo are primarily orchestrated by their secretome of paracrine factors and cell-matrix interactions. More recent developments are focused on creating more complex structures such as 3D organoids, tissue elements and eventually fully functional tissues and organs to replace or repair diseased or damaged tissues. The current and future applications for ASCs in regenerative medicine are discussed here.
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