Dry-media one-pot syntheses of fluorinated-2,3-dihydro-1,5-benzothiazepines under microwave activation

被引：66
作者：
Dandia, A [1 ]
Sati, M
Loupy, A
机构：
[1] Univ Rajasthan, Dept Chem, Jaipur 302004, Rajasthan, India
[2] Univ Paris 11, Lab React Select Supports, ICMMO, UMR 8615, F-91405 Orsay, France
来源：
GREEN CHEMISTRY | 2002年 / 4卷 / 06期
关键词：
D O I：
10.1039/b207004a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new efficient and environmentally friendly green chemistry procedure for the syntheses of a series of 8-substituted-2-carboxy-2,3-dihydro-1,5-benzothiazepines under microwave irradiation and solvent-free conditions is described. Results were compared with those obtained following classical thermal method. A judicious choice of the reaction conditions allowed the final products 4a-f to be generated in excellent yields in a one-step procedure, whereas experiments under thermal conditions led to benzothiazepines along with other products in lower yields with tedious work-up.
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页码：599 / 602
页数：4
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