Soluble receptor for advanced glycation end products in late onset neonatal infection

被引:5
作者
Zolakova, B. [1 ]
Zolak, V [2 ]
Hatok, J. [3 ]
Matasova, K. [1 ]
Nosal, S. [2 ]
Zibolen, M. [1 ]
机构
[1] Comenius Univ, Jessenius Fac Med Martin, Dept Neonatol, Univ Hosp Martin, Bratislava 81806, Slovakia
[2] Comenius Univ, Jessenius Fac Med Martin, Dept Paediat Anaesthesiol & Intens Med, Univ Hosp Martin, Bratislava 81806, Slovakia
[3] Comenius Univ, Jessenius Fac Med Martin, Dept Med Biochem, Bratislava 81806, Slovakia
来源
BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY | 2016年 / 117卷 / 01期
关键词
sRAGE; biomarker; preterm neonate; late-onset infection; late-onset sepsis; PRETERM BIRTH; INJURY; HMGB1; SRAGE; RAGE;
D O I
10.4149/BLL_2016_003
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVES: To assess the plasma levels of sRAGE (soluble receptor for advanced glycation end products) in infected and non-infected preterm neonates and to compare their diagnostic values with standard infection biomarkers. BACKGROUND: RAGE activates pathways responsible for acute and chronic inflammation. The soluble type of this receptor, sRAGE, which acts as a decoy receptor, has been linked to the severity of sepsis and its outcome. METHODS: Prospective clinical study was carried out from January 2011 to August 2013. There were 33 neonates included according to their infection status and divided into subgroups as follows: infected (I), septic (S), non-infected controls (C). RESULTS: We found significantly lower values of sRAGE in the subgroup S (905.54+/-220.53 pg/mL; p < 0.028), while borderline values were higher in the subgroup I vs C (2158.33+/-197.33 pg/mL vs 1744.80+/-157.74 pg/mL; p < 0.064). By analysing the interobserver concordance we detected 70 % agreement as to sRAGE values detected in neonatal late-onset infections and sepsis, while procalcitonin was used as golden standard. CONCLUSION: Plasma sRAGE values reflect the severity of the inflammatory status in late-onset infection and sepsis in preterm neonates. Our results indicate that sRAGE could be a good potential biomarker of late-onset neonatal infection and sepsis (Tab. 2, Ref. 14). Text in PDF www.elis.sk.
引用
收藏
页码:15 / 18
页数:4
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