Bioactive Iridoid Glycosides from the Whole Plants of Rehmannia chingii

被引：30

作者：

Liu, Yan-Fei

Shi, Guo-Ru

Wang, Xin

Zhang, Chun-Lei

Wang, Yan

Chen, Ruo-Yun

Yu, De-Quan ^{[1
]}

机构：

[1] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Substance & Funct Nat Med, Beijing 100050, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2016年 / 79卷 / 02期

基金：

中国国家自然科学基金;

关键词：

RADIX; ROOTS;

D O I：

10.1021/acs.jnatprod.5b01126

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Nine new iridoid glycosides, rehmachingiiosides A-I (1-9), together with 16 known analogues, were isolated from the whole plants of Rehmannia chingii. The structures of compounds 1-9 were elucidated on the basis of spectroscopic data analysis and from chemical evidence. Furthermore, in two vitro assays, compounds 5 and 10 showed an inhibitory effect on LPS-induced NO production with IC50 values of 2.5 and 7.3 mu M, and compounds 4, 6, and 10-12 (when evaluated at 10 mu M) exhibited evidence of hepatoprotective effects against APAP-induced HepG2 cell damage.

引用

页码：428 / 433

页数：6

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