Is SENS a farrago?

SENS (Strategies for Engineered Negligible Senescence) is a panel of proposed interventions in mammalian aging that I have suggested may be sufficiently feasible, comprehensive, and amenable to subsequent incremental refinement that it could prevent death from old age (at any age) within a time frame of decades, leading to four-digit lifespans of many people alive today. This extreme conclusion has drawn sharp criticism from some colleagues, especially because the methodology of SENS departs radically from approaches generally considered the most promising ways to combat aging and because it is perceived as endangering biogerontology's respectability. Here I briefly respond to these criticisms.