Circadian rhythms - Finer clock control

被引:21
作者
Alvarez, JD
Sehgal, A
机构
[1] Hosp Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA
[2] Univ Penn, Sch Med, Dept Neurosci, Howard Hughes Med Inst, Philadelphia, PA 19104 USA
关键词
D O I
10.1038/419798a
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The clock that governs circadian rhythms is based on a molecular feedback loop, which has just become more complex - Two more proteins have been identified as likely components of the loop. © 2002 Nature Publishing Group.
引用
收藏
页码:798 / 799
页数:2
相关论文
共 10 条
[1]   Role of the CLOCK protein in the mammalian circadian mechanism [J].
Gekakis, N ;
Staknis, D ;
Nguyen, HB ;
Davis, FC ;
Wilsbacher, LD ;
King, DP ;
Takahashi, JS ;
Weitz, CJ .
SCIENCE, 1998, 280 (5369) :1564-1569
[2]   Dec1 and Dec2 are regulators of the mammalian molecular clock [J].
Honma, S ;
Kawamoto, T ;
Takagi, Y ;
Fujimoto, K ;
Sato, F ;
Noshiro, M ;
Kato, Y ;
Honma, K .
NATURE, 2002, 419 (6909) :841-+
[3]   Helix-loop-helix proteins: Regulators of transcription in eucaryotic organisms [J].
Massari, ME ;
Murre, C .
MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (02) :429-440
[4]   Coordinated transcription of key pathways in the mouse by the circadian clock [J].
Panda, S ;
Antoch, MP ;
Miller, BH ;
Su, AI ;
Schook, AB ;
Straume, M ;
Schultz, PG ;
Kay, SA ;
Takahashi, JS ;
Hogenesch, JB .
CELL, 2002, 109 (03) :307-320
[5]   TRANSPLANTED SUPRACHIASMATIC NUCLEUS DETERMINES CIRCADIAN PERIOD [J].
RALPH, MR ;
FOSTER, RG ;
DAVIS, FC ;
MENAKER, M .
SCIENCE, 1990, 247 (4945) :975-978
[6]   Molecular analysis of mammalian circadian rhythms [J].
Reppert, SM ;
Weaver, DR .
ANNUAL REVIEW OF PHYSIOLOGY, 2001, 63 :647-676
[7]   Coordination of circadian timing in mammals [J].
Reppert, SM ;
Weaver, DR .
NATURE, 2002, 418 (6901) :935-941
[8]   Interacting molecular loops in the mammalian circadian clock [J].
Shearman, LP ;
Sriram, S ;
Weaver, DR ;
Maywood, ES ;
Chaves, I ;
Zheng, BH ;
Kume, K ;
Lee, CC ;
van der Horst, GTJ ;
Hastings, MH ;
Reppert, SM .
SCIENCE, 2000, 288 (5468) :1013-1019
[9]   Molecular characterization of the novel basic helix-loop-helix protein DEC1 expressed in differentiated human embryo chondrocytes [J].
Shen, M ;
Kawamoto, T ;
Yan, WQ ;
Nakamasu, K ;
Koyano, Y ;
Noshiro, M ;
Kato, Y .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 236 (02) :294-298
[10]   A transcription factor response element for gene expression during circadian night [J].
Ueda, HR ;
Chen, WB ;
Adachi, A ;
Wakamatsu, H ;
Hayashi, S ;
Takasugi, T ;
Nagano, M ;
Nakahama, K ;
Suzuki, Y ;
Sugano, S ;
Iino, M ;
Shigeyoshi, Y ;
Hashimoto, S .
NATURE, 2002, 418 (6897) :534-539