EGFR/ERBB receptors differentially modulate sebaceous lipogenesis

被引：24

作者：

Dahlhoff, Maik ^{[1
]}

Camera, Emanuela ^{[2
,3
]}

Ludovici, Matteo ^{[2
,3
]}

Picardo, Mauro ^{[2
,3
]}

Mueller, Udo ^{[4
]}

Leonhardt, Heinrich ^{[4
]}

Zouboulis, Christos C. ^{[5
,6
,7
,8
]}

Schneider, Marlon R. ^{[1
]}

机构：

[1] Ludwig Maximilians Univ Munchen, Gene Ctr, Inst Mol Anim Breeding & Biotechnol, D-81377 Munich, Germany

[2] IRCCS, San Gallicano Dermatol Inst, Lab Cutaneous Physiopathol, Rome, Italy

[3] IRCCS, San Gallicano Dermatol Inst, Integrated Ctr Metabol Res, Rome, Italy

[4] Ludwig Maximilians Univ Munchen, Dept Biol 2, Human Biol & BioImaging, D-81377 Munich, Germany

[5] Dessau Med Ctr, Dept Dermatol, Dessau, Germany

[6] Dessau Med Ctr, Dept Venereol, Dessau, Germany

[7] Dessau Med Ctr, Dept Allergol, Dessau, Germany

[8] Dessau Med Ctr, Dept Immunol, Dessau, Germany

来源：

FEBS LETTERS | 2015年 / 589卷 / 12期

关键词：

Sebaceous gland; Epidermal growth factor receptor; ERBB; Sebaceous lipogenesis; EPIDERMAL-GROWTH-FACTOR; SIGNAL-TRANSDUCTION; HUMAN KERATINOCYTES; TYROSINE KINASES; GLAND SIZE; IN-VITRO; EXPRESSION; ACNE; FAMILY; MICE;

D O I：

10.1016/j.febslet.2015.04.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The roles of the epidermal growth factor receptor (EGFR) in sebaceous glands remain poorly explored. We show that human sebocytes express EGFR and lower levels of ERBB2 and ERBB3, all receptors being downregulated after the induction of lipid synthesis. Nile red staining showed that siRNA-mediated downregulation of EGFR or ERBB3 increases lipid accumulation, whereas ERBB2 downregulation has no effect. Spectrometry confirmed induction of triglycerides after EGFR or ERBB3 downregulation and revealed induction of cholesteryl esters after downregulation of EGFR, ERBB2 or ERBB3. Thus, EGFR/ERBB receptors differentially modulate sebaceous lipogenesis, a key feature of sebaceous gland physiology and of several skin diseases. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：1376 / 1382

页数：7

共 35 条

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