What brings pericytes to tumor vessels?

被引：142
作者：
Jain, RK
Booth, MF
机构：
[1] Harvard Univ, Sch Med, Edwin L Steele Lab, Dept Radiat Oncol, Boston, MA 02114 USA
[2] Massachusetts Gen Hosp, Edwin L Steele Lab, Dept Radiat Oncol, Boston, MA 02114 USA
来源：
JOURNAL OF CLINICAL INVESTIGATION | 2003年 / 112卷 / 08期
关键词：
BLOOD-VESSELS; CELLS; INDUCTION; VEGF; ANGIOGENESIS; RECRUITMENT; VASCULATURE; EXPRESSION; PDGF;
D O I：
10.1172/JCI200320087
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Paracrine signaling via platelet-derived growth factor B (PDGFB), expressed by endothelial cells, and its receptor PDGFR-beta, expressed by pericytes, plays a central role in blood vessel maturation. A new study (see the related article beginning on page 1142) reveals that it is not just the presence of PDGFB, but how it is presented to pericytes, that determines the quality of the endothelium-pericyte interaction.
引用
收藏
页码：1134 / 1136
页数：3
相关论文
共 18 条
  • [1] Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors
    Abramsson, A
    Lindblom, P
    Betsholtz, C
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2003, 112 (08) : 1142 - 1151
  • [2] Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal
    Benjamin, LE
    Golijanin, D
    Itin, A
    Pode, D
    Keshet, E
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1999, 103 (02) : 159 - 165
  • [3] Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors
    Bergers, G
    Song, S
    Meyer-Morse, N
    Bergsland, E
    Hanahan, D
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2003, 111 (09) : 1287 - 1295
  • [4] In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy
    Brown, EB
    Campbell, RB
    Tsuzuki, Y
    Xu, L
    Carmeliet, P
    Fukumura, D
    Jain, RK
    [J]. NATURE MEDICINE, 2001, 7 (07) : 864 - 868
  • [5] Angiogenesis in health and disease
    Carmeliet, P
    [J]. NATURE MEDICINE, 2003, 9 (06) : 653 - 660
  • [6] Global expression profiling of fibroblast responses to transforming growth factor-β1 reveals the induction of inhibitor of differentiation-1 and provides evidence of smooth muscle cell phenotypic switching
    Chambers, RC
    Leoni, P
    Kaminski, N
    Laurent, GJ
    Heller, RA
    [J]. AMERICAN JOURNAL OF PATHOLOGY, 2003, 162 (02) : 533 - 546
  • [7] Tumor induction of VEGF promoter activity in stromal cells
    Fukumura, D
    Xavier, R
    Sugiura, T
    Chen, Y
    Park, EC
    Lu, NF
    Selig, M
    Nielsen, G
    Taksir, T
    Jain, RK
    Seed, B
    [J]. CELL, 1998, 94 (06) : 715 - 725
  • [8] Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis
    Hellström, M
    Gerhardt, H
    Kalén, M
    Li, XR
    Eriksson, U
    Wolburg, H
    Betsholtz, C
    [J]. JOURNAL OF CELL BIOLOGY, 2001, 153 (03) : 543 - 553
  • [9] PDGF, TGF-β, and heterotypic cell-cell interactions mediate endothelial cell-induced recruitment of 10T1/2 cells and their differentiation to a smooth muscle fate
    Hirschi, KK
    Rohovsky, SA
    D'Amore, PA
    [J]. JOURNAL OF CELL BIOLOGY, 1998, 141 (03) : 805 - 814
  • [10] Regulation of transport pathways in tumor vessels: Role of tumor type and microenvironment
    Hobbs, SK
    Monsky, WL
    Yuan, F
    Roberts, WG
    Griffith, L
    Torchilin, VP
    Jain, RK
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (08) : 4607 - 4612
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