Fungal epoxide hydrolases: new tools for the synthesis of enantiopure epoxides and diols

被引：22

作者：

Archelas, A ^{[1
]}

机构：

[1] Fac Sci Luminy, URA CNRS 1320, Grp Chim Organ & Bioorgan, F-13288 Marseille 9, France

来源：

JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC | 1998年 / 5卷 / 1-4期

关键词：

fungal epoxide hydrolase; enantioselectivity; optical resolution; epoxide; 1,2-diol;

D O I：

10.1016/S1381-1177(98)00011-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This presentation describes efficient means of preparing optically pure epoxides and diols using fungal epoxide hydrolases as biocatalysts. The biohydrolyses can be carried out in a preparative scale for different types of epoxides as terpenic-, aliphatic-, aromatic- and glycidyl acetal-derivatives bearing an epoxide moiety. In addition, in order to obtain these compounds in good yield, an efficient enzymatic reactor and different enantioconvergent processes were devised. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：79 / 85

页数：7

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