Birth and evolution of the desmoplastic small round-cell tumor

被引：4

作者：

de Alava, Enrique ^{[1
,2
]}

Marcilla, David ^{[1
,2
]}

机构：

[1] Univ Seville, CSIC, Dept Pathol, Inst Biomed Sevilla IBiS,Virgen del Rocio Univ Ho, Seville 41013, Spain

[2] AGS Osuna, La Merced Hosp, Dept Pathol, Osuna, Spain

来源：

SEMINARS IN DIAGNOSTIC PATHOLOGY | 2016年 / 33卷 / 05期

关键词：

sarcoma; Pathology; Molecular Pathology; EWSR1; gene; WT1; desmoplasia; EWS-WT1 GENE FUSION; MODULATED RADIATION-THERAPY; CHIMERIC TRANSCRIPTS; ONCOGENIC PROPERTIES; TRANSLOCATION; SPECTRUM; EWS/WT1; DIFFERENTIATION; EMPHASIS; VARIANTS;

D O I：

10.1053/j.semdp.2016.05.003

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

The first large series of desmoplastic small round cell tumor was reported twenty-five years ago. This article reviews the original characterization of this neoplasm, and the eventual expansion of its clinical and pathological spectrum. Relevant data on its molecular features are summarized, in order to understand the search for therapeutic targets. The challenge ahead is to better know and cure this disease through the finding and validation of actionable therapeutic targets. (C) 2016 Elsevier Inc. All rights reserved.

引用

收藏

页码：254 / 261

页数：8

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