The role of Na+-K+-ATPase in the epileptic brain

被引：29
作者：
Sun, Jinyi [1 ]
Zheng, Yang [2 ]
Chen, Zhong [1 ,2 ,3 ]
Wang, Yi [1 ,2 ,3 ]
机构：
[1] Zhejiang Univ, Inst Pharmacol & Toxicol, Coll Pharmaceut Sci, Hangzhou 310058, Peoples R China
[2] Zhejiang Chinese Med Univ, Sch Pharmaceut Sci, Key Lab Neuropharmacol & Translat Med Zhejiang Pr, Hangzhou, Peoples R China
[3] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Epilepsy Ctr,Dept Neurol, Hangzhou, Peoples R China
来源：
CNS NEUROSCIENCE & THERAPEUTICS | 2022年 / 28卷 / 09期
基金：
中国国家自然科学基金;
关键词：
drug target; epilepsy; excitability; Na plus -K plus -ATPase; FAMILIAL HEMIPLEGIC MIGRAINE; DE-NOVO MUTATIONS; CRYSTAL-STRUCTURE; CEREBRAL-CORTEX; P2X7; RECEPTOR; ATP1A2; NA; K-ATPASE; NA+; K+-ATPASE; PILOCARPINE; SEIZURES;
D O I：
10.1111/cns.13893
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Na+-K+-ATPase, a P-type ATP-powered ion transporter on cell membrane, plays a vital role in cellular excitability. Cellular hyperexcitability, accompanied by hypersynchronous firing, is an important basis for seizures/epilepsy. An increasing number of studies point to a significant contribution of Na+-K+-ATPase to epilepsy, although discordant results exist. In this review, we comprehensively summarize the structure and physiological function of Na+-K+-ATPase in the central nervous system and critically evaluate the role of Na+-K+-ATPase in the epileptic brain. Importantly, we further provide perspectives on some possible research directions and discuss its potential as a therapeutic target for the treatment of epilepsy.
引用
收藏
页码：1294 / 1302
页数：9
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