A General and Efficient Method to Access Tetracyclic Spirooxindole Derivatives

被引：15

作者：

El Bouakher, Abderrahman ^{[1
]}

Massip, Stephane ^{[2
]}

Jarry, Christian ^{[2
]}

Troin, Yves ^{[3
,4
]}

Abrunhosa-Thomas, Isabelle ^{[3
,4
]}

Guillaumet, Gerald ^{[1
]}

机构：

[1] Univ Orleans, CNRS, UMR 7311, Inst Chim Organ & Analyt, F-45067 Orleans, France

[2] Univ Bordeaux Segalen, CNRS, FRE 3396, F-33000 Bordeaux, France

[3] Clermont Univ, ENSCCF, ICCF, F-63000 Clermont Ferrand, France

[4] ICCF, CNRS, UMR 6296, F-63171 Aubiere, France

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2015年 / 2015卷 / 03期

关键词：

Anionic condensation; Reduction; Cyclization; Selective deprotection; Tetracyclic spirooxindole; Spiro compounds; REVERSE-TRANSCRIPTASE INHIBITORS; ENANTIOSELECTIVE SYNTHESIS; BIOLOGICAL EVALUATIONS; STRESS METABOLITES; METALATION; OXINDOLES; BIOSYNTHESIS; PHYTOALEXIN; CARBOLINES; FRAGMENT;

D O I：

10.1002/ejoc.201403292

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient, simple, and convenient synthetic procedure for the synthesis of tetracyclic spirooxindole derivatives, starting from N-protected isatins and 2-fluoropyridine, was success-fully developed. It enables the facile formation of a new class of spirooxindoles in which the oxindole core is fused with various heterocycles at the C-3 position.

引用

页码：556 / 569

页数：14

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