Association of MTHFR 677C?>?T and 1298A?>?C polymorphisms with susceptibility to attention deficit and hyperactivity disorder

被引：8
|
作者：
Sadeghiyeh, Tahereh [1 ]
Dastgheib, Seyed Alireza [2 ]
Lookzadeh, Mohamad Hosein [3 ]
Noori-Shadkam, Mahmood [3 ]
Akbarian-Bafghi, Mohammad Javad [4 ]
Zare-Shehneh, Masoud [5 ]
Poursharif, Zahra [6 ]
Neamatzadeh, Hossein [5 ,7 ]
机构：
[1] Shahid Sadoughi Univ Med Sci, Child & Adolescent Psychiat Res Ctr Addit Behav S, Yazd, Iran
[2] Shiraz Univ Med Sci, Sch Med, Dept Med Genet, Shiraz, Iran
[3] Shahid Sadoughi Univ Med Sci, Dept Pediat, Yazd, Iran
[4] Barn Univ Med Sci, Dept Healthcare Management, Barn, Iran
[5] Shahid Sadoughi Univ Med Sci, Dept Med Genet, Yazd, Iran
[6] Univ Tehran Med Sci, Sch Med, Dept Psychol, Tehran, Iran
[7] Shahid Sadoughi Univ Med Sci, Mother & Newborn Hlth Res Ctr, Yazd, Iran
来源：
FETAL AND PEDIATRIC PATHOLOGY | 2020年 / 39卷 / 05期
关键词：
Attention deficit and hyperactivity disorder; MTHFR gene; folate; single nucleotide polymorphism; REDUCTASE GENE POLYMORPHISMS; CHILDREN; PREGNANCY; CHILDHOOD; C677T; RISK;
D O I：
10.1080/15513815.2019.1666330
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Background: The associations of MTHFR polymorphisms with risk of attention deficit and hyperactivity disorder (ADHD) are poorly elucidated. This study was performed to evaluate the association of MTHFR polymorphisms with ADHD risk in Iranian children. Methods: This case?control study included 214 children with ADHD and 220 healthy subjects. The MTHFR 677C?>?T and 1298A?>?C polymorphisms were genotyped by an ABI PRISMs 7500 real-time PCR System. The odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of the association. Results: The MTHFR 1298A?>?C polymorphism CC genotype (OR= 1.526, 95% CI 1.004?2.320, p?=?0.048) and C allele (OR= 1.336, 95% CI 0.1023?1.745, p?=?0.034) were associated with an increased risk of ADHD. There was no significant association between MTHFR 677C?>?T polymorphism and increased risk of ADHD. Conclusions: Our results revealed that the MTHFR 1298A?>?C polymorphism but not the MTHFR 677?C?>?T is associated with increased risk of ADHD in Iranian children.
引用
收藏
页码：422 / 429
页数：8
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