Dissemination and growth of cancer cells in metastatic sites

被引：2984

作者：

Chambers, AF

Groom, AC

MacDonald, IC

机构：

[1] London Reg Canc Ctr, London, ON N6A 4L6, Canada

[2] Univ Western Ontario, Dept Oncol, London, ON N6A 4L6, Canada

[3] Univ Western Ontario, Dept Med Biophys, London, ON N6A 5C1, Canada

来源：

NATURE REVIEWS CANCER | 2002年 / 2卷 / 08期

基金：

加拿大健康研究院;

关键词：

D O I：

10.1038/nrc865

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Metastases, rather than primary tumours, are responsible for most cancer deaths. To prevent these deaths, improved ways to treat metastatic disease are needed. Blood flow and other mechanical factors influence the delivery of cancer cells to specific organs, whereas molecular interactions between the cancer cells and the new organ influence the probability that the cells will grow there. Inhibition of the growth of metastases in secondary sites offers a promising approach for cancer therapy.

引用

页码：563 / 572

页数：10

共 102 条

[61] INFLUENCE OF ORGAN ENVIRONMENT ON EXTRACELLULAR-MATRIX DEGRADATIVE ACTIVITY AND METASTASIS OF HUMAN COLON-CARCINOMA CELLS [J].