Anti-proliferative activity and structure-activity relationship of honokiol derivatives

被引：21

作者：

Lin, Ding ^{[1
,2
]}

Yan, Zhongzhong ^{[1
]}

Chen, Aiyu ^{[1
]}

Ye, Jiao ^{[1
]}

Hu, Aixi ^{[1
]}

Liu, Juan ^{[3
]}

Peng, Junmei ^{[3
]}

Wu, Xiaoyun ^{[4
]}

机构：

[1] Hunan Univ, Coll Chem & Chem Engn, Changsha 410082, Hunan, Peoples R China

[2] Zhejiang A&F Univ, Dept Tradit Chinese Med, Hangzhou 311300, Zhejiang, Peoples R China

[3] Univ South China, Coll Pharm & Biol Sci, Hengyang 421000, Peoples R China

[4] Southern Med Univ, Guangdong Prov Key Lab New Drug Screening, Sch Pharmaceut Sci, Guangzhou 510515, Guangdong, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2019年 / 27卷 / 16期

基金：

中国国家自然科学基金;

关键词：

Honokiol; Anti-proliferative; Structure-activity relationship; 3D-QASR; Theoretical calculations; NATURAL-PRODUCT; MAGNOLIA-OFFICINALIS; LIPOSOMAL HONOKIOL; CANCER-CELLS; IN-VITRO; ANGIOGENESIS; CYTOTOXICITY; INHIBITION; APOPTOSIS; PROTEIN;

D O I：

10.1016/j.bmc.2019.06.042

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

As a known natural product with anti-tumor activity, honokiol has been widely researched and structural modified. Lots of honokiol derivatives have been found to possess good anti-proliferative activity and showed great potential in cancer therapy, but the SAR (structure-activity relationship) was still confused. Here in, the SAR were comprehensively researched by summary of reported derivatives and synthesis of novel derivatives. Amongst novel derivatives, the promising compounds A6 and A10 exhibited potent and selective anti-proliferative activities against K562 cell line with the IC50 values of 5.04 and 7.08 mu M respectively. The SAR was discussed around honokiol and 79 derivatives by the means of CoMFA and theoretical calculation, which provided useful suggestion for further structural optimization of honokiol derivatives.

引用

页码：3729 / 3734

页数：6

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