Maternal anxiety, depression and asthma and adverse pregnancy outcomes - a population based study

被引:43
作者
Rejno, Gustaf [1 ,2 ]
Lundholm, Cecilia [1 ]
Oberg, Sara [1 ]
Lichtenstein, Paul [1 ]
Larsson, Henrik [1 ,3 ]
D'Onofrio, Brian [1 ,4 ]
Larsson, Kjell [5 ]
Saltvedt, Sissel [6 ,7 ]
Brew, Bronwyn K. [1 ]
Almqvist, Catarina [1 ,8 ]
机构
[1] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden
[2] Soderjukhuset, Obstet & Gynaecol Unit, Stockholm, Sweden
[3] Orebro Univ, Sch Med Sci, Orebro, Sweden
[4] Indiana Univ, Dept Psychol & Brain Sci, Bloomington, IN USA
[5] Karolinska Inst, Inst Environm Med, Stockholm, Sweden
[6] Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden
[7] Karolinska Univ Hosp, Obstet & Gynaecol Unit, Stockholm, Sweden
[8] Karolinska Univ Hosp, Astrid Lindgren Childrens Hosp, Pediat Allergy & Pulmonol Unit, Stockholm, Sweden
基金
瑞典研究理事会;
关键词
PRETERM BIRTH; GESTATIONAL-AGE; SYMPTOMS; IMPACT; RISK; DISORDERS; ASSOCIATION; PREVALENCE; MOTHERS; TWINS;
D O I
10.1038/s41598-019-49508-z
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
To evaluate associations between maternal anxiety or depression and adverse pregnancy outcomes, taking possible familial confounding and interaction with asthma into account, we conducted a cohort study of all singleton births in Sweden 2001-2013. We retrieved information about pregnancy, diagnoses of anxiety/depression, asthma, and prescribed medication from the Swedish Medical Birth, National Patient, and Prescribed Drug Registers. We estimated associations with regression models, performed cousin and sibling comparisons, and calculated interactions. In 950 301 identified pregnancies; 5.9% had anxiety/depression and 4.0% had asthma. Anxiety/depression was associated with adverse pregnancy outcomes (e.g. preeclampsia, adjusted Odds Ratio 1.17 (95% Confidence Interval 1.12, 1.22), instrumental delivery (1.14 (1.10, 1.18)), elective (1.62 (1.57, 1.68)) and emergency (1.32 (1.28,1.35)) caesarean section (CS)). Their children had lower birth weight (-54 g (-59, -49)) and shorter gestational age (-0.29 weeks (-0.31, -0.28)). Associations were not confounded by familial factors and asthma did not modify the effect of anxiety/depression for outcomes other than elective CS, p < 0.001. In women with anxiety/depression diagnosis, untreated women had higher odds of elective CS compared to women on medication (1.30 (1.17,1.43)). In conclusion, anxiety/depression should be considered when evaluating pregnant women's risk of complications such as preeclampsia and non-vaginal deliveries.
引用
收藏
页数:9
相关论文
共 46 条
[1]   Prenatal Depression and Adverse Birth Outcomes: An Updated Systematic Review [J].
Accortt, Eynav Elgavish ;
Cheadle, Alyssa C. D. ;
Schetter, Christine Dunkel .
MATERNAL AND CHILD HEALTH JOURNAL, 2015, 19 (06) :1306-1337
[2]  
[Anonymous], 2003, SWED MED BIRTH REG S
[3]   Effect of depressive and anxiety symptoms during pregnancy on risk of obstetric interventions [J].
Bayrampour, Hamideh ;
Salmon, Charleen ;
Vinturache, Angela ;
Tough, Suzanne .
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, 2015, 41 (07) :1040-1048
[4]   Prevalence of depression during pregnancy: Systematic review [J].
Bennett, HA ;
Einarson, A ;
Taddio, A ;
Koren, G ;
Einarson, TR .
OBSTETRICS AND GYNECOLOGY, 2004, 103 (04) :698-709
[5]   The Increasing Trend in Caesarean Section Rates: Global, Regional and National Estimates: 1990-2014 [J].
Betran, Ana Pilar ;
Ye, Jianfeng ;
Moller, Anne-Beth ;
Zhang, Jun ;
Guelmezoglu, A. Metin ;
Torloni, Maria Regina .
PLOS ONE, 2016, 11 (02)
[6]   Longitudinal depression or anxiety in mothers and offspring asthma: a Swedish population-based study [J].
Brew, Bronwyn K. ;
Lundholm, Cecilia ;
Viktorin, Alexander ;
Lichtenstein, Paul ;
Larsson, Henrik ;
Almqvist, Catarina .
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2018, 47 (01) :166-174
[7]   Mothers' anxiety during pregnancy is associated with asthma in their children [J].
Cookson, Hannah ;
Granell, Raquel ;
Joinson, Carol ;
Ben-Shlomo, Yoav ;
Henderson, A. John .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2009, 123 (04) :847-853
[8]   Translational Epidemiologic Approaches to Understanding the Consequences of Early-Life Exposures [J].
D'Onofrio, Brian M. ;
Class, Quetzal A. ;
Rickert, Martin E. ;
Sujan, Ayesha C. ;
Larsson, Henrik ;
Kuja-Halkola, Ralf ;
Sjolander, Arvid ;
Almqvist, Catarina ;
Lichtenstein, Paul ;
Oberg, A. Sara .
BEHAVIOR GENETICS, 2016, 46 (03) :315-328
[9]   Critical Need for Family-Based, Quasi-Experimental Designs in Integrating Genetic and Social Science Research [J].
D'Onofrio, Brian M. ;
Lahey, Benjamin B. ;
Turkheimer, Eric ;
Lichtenstein, Paul .
AMERICAN JOURNAL OF PUBLIC HEALTH, 2013, 103 :46-55
[10]  
Einarson A, 2001, J PSYCHIATR NEUROSCI, V26, P44