Synthesis of 2',3'-dihydrosolanesyl analogues of β-D-arabinofuranosyl-1-monophosphoryldecaprenoI with promising antimycobacterial activity

被引：24

作者：

Bosco, Michael

Bisseret, Philippe

Constant, Patricia

Eustache, Jacques

机构：

[1] Univ Haute Alsace, Ecole Natl Super Chim Mulhouse, CNRS, Lab Chim Organ & Bioorgan Assoc, F-69093 Mulhouse, France

[2] CNRS, UMR 5089, Inst Pharmacol & Biol Struct, F-31077 Toulouse 4, France

来源：

TETRAHEDRON LETTERS | 2007年 / 48卷 / 01期

关键词：

D O I：

10.1016/j.tetlet.2006.10.151

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two new hydrolytically stable analogues of beta-D-arabinofuranosyl-1-monophosphoryldecaprenol, the donor substrate for mycobacterial arabinosyltransferase, have been prepared. Biological evaluation of these compounds in vitro against Mycobacterium tuberculosis H(37)Rv strain revealed a promising activity. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：153 / 157

页数：5

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