The neuropsychopharmacology of cannabis: A review of human imaging studies

被引：162

作者：

Bloomfield, Michael A. P. ^{[1
,2
,3
,4
,5
]}

Hindocha, Chandni ^{[1
,2
,4
]}

Green, Sebastian F. ^{[1
]}

Wall, Matthew B. ^{[2
,6
,7
]}

Lees, Rachel ^{[1
,2
,8
]}

Petrilli, Katherine ^{[1
,2
,8
]}

Costello, Harry ^{[1
]}

Ogunbiyi, M. Olabisi ^{[1
]}

Bossong, Matthijs G. ^{[9
]}

Freeman, Tom P. ^{[1
,2
,10
,11
]}

机构：

[1] UCL, Translat Psychiat Res Grp, Res Dept Mental Hlth Neurosci, Div Psychiat,Fac Brain Sci, London, England

[2] UCL, Fac Brain Sci, Res Dept Clin Educ & Hlth Psychol, Clin Psychopharmacol Unit, London, England

[3] Hammersmith Hosp, MRC London Inst Med Sci, Psychiat Imaging Grp, London, England

[4] Univ Coll Hosp, NIHR Univ Coll London Hosp Biomed Res Ctr, London, England

[5] Imperial Coll London, Fac Med, Inst Clin Sci, London, England

[6] Imperial Coll London, Fac Med, Div Brain Sci, Ctr Neuropsychopharmacol, London, England

[7] Hammersmith Hosp, Invicro UK, London, England

[8] UCL, Fac Brain Sci, Inst Cognit Neurosci, London, England

[9] Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Psychiat, Utrecht, Netherlands

[10] Univ Bath, Dept Psychol, Bath, Avon, England

[11] Kings Coll London, Inst Psychiat Psychol & Neurosci, Natl Addict Ctr, London, England

来源：

PHARMACOLOGY & THERAPEUTICS | 2019年 / 195卷

基金：

英国医学研究理事会;

关键词：

Addiction; Cannabis; Cognition; Development; Neuroimaging; Psychosis; CEREBRAL-BLOOD-FLOW; SPATIAL WORKING-MEMORY; D-2/D-3 RECEPTOR AVAILABILITY; STRIATAL DOPAMINE RELEASE; ANTERIOR CINGULATE CORTEX; EARLY-ONSET SCHIZOPHRENIA; FREQUENT MARIJUANA USE; HIGH-POTENCY CANNABIS; MAGNETIC-RESONANCE; FUNCTIONAL CONNECTIVITY;

D O I：

10.1016/j.pharmthera.2018.10.006

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The laws governing cannabis are evolving worldwide and associated with changing patterns of use. The main psychoactive drug in cannabis is Delta(9)-tetrahydrocannabinol (THC), a partial agonist at the endocannabinoid CB1 receptor. Acutely, cannabis and THC produce a range of effects on several neurocognitive and pharmacological systems. These include effects on executive, emotional, reward and memory processing via direct interactions with the endocannabinoid system and indirect effects on the glutamatergic, GABAergic and dopaminergic systems. Cannabidiol, a non-intoxicating cannabinoid found in some forms of cannabis, may offset some of these acute effects. Heavy repeated cannabis use, particularly during adolescence, has been associated with adverse effects on these systems, which increase the risk of mental illnesses including addiction and psychosis. Here, we provide a comprehensive state of the art review on the acute and chronic neuropsychopharmacology of cannabis by synthesizing the available neuroimaging research in humans. We describe the effects of drug exposure during development, implications for understanding psychosis and cannabis use disorder, and methodological considerations. Greater understanding of the precise mechanisms underlying the effects of cannabis may also give rise to new treatment targets. (C) 2018 The Authors. Published by Elsevier Inc.

引用

页码：132 / 161

页数：30

共 325 条

[11]

[Anonymous], FRONTIERS PHARM

[12] Cannabis-induced psychosis and subsequent schizophrenia-spectrum disorders: follow-up study of 535 incident cases [J].