Revisiting the Regenerative Therapeutic Advances Towards Erectile Dysfunction

被引：32

作者：

Liu, Ming-Che ^{[1
,2
,3
,4
]}

Chang, Meng-Lin ^{[5
,6
,7
]}

Wang, Ya-Chun ^{[8
]}

Chen, Wei-Hung ^{[8
]}

Wu, Chien-Chih ^{[1
,9
]}

Yeh, Shauh-Der ^{[10
,11
]}

机构：

[1] Taipei Med Univ Hosp, Dept Urol, Taipei 11031, Taiwan

[2] Taipei Med Univ Hosp, Clin Res Ctr, Taipei 11031, Taiwan

[3] Taipei Med Univ, Grad Inst Clin Med, Sch Med, Coll Med, Taipei 11031, Taiwan

[4] Taipei Med Univ, Sch Dent Technol, Coll Oral Med, Taipei 11031, Taiwan

[5] Fu Jen Catholic Univ, Fu Jen Catholic Univ Hosp, Dept Urol, New Taipei 242, Taiwan

[6] Fu Jen Catholic Univ, Sch Med, Coll Med, New Taipei 242, Taiwan

[7] Fu Jen Catholic Univ, Grad Inst Appl Sci & Engn, New Taipei 242, Taiwan

[8] TCM Biotech Int Corp, New Taipei 22175, Taiwan

[9] Taipei Med Univ, Sch Med, Dept Educ & Humanities Med, Coll Med, Taipei 11031, Taiwan

[10] Taipei Med Univ Hosp, Dept Urol & Oncol, Taipei 11031, Taiwan

[11] Taipei Med Univ, Sch Med, Dept Urol, Coll Med, Taipei 11031, Taiwan

来源：

CELLS | 2020年 / 9卷 / 05期

关键词：

erectile dysfunction (ED); platelet-rich plasma (PRP); platelet-derived biomaterials; stem cells; regenerative therapy; intracavernosal injection; intracavernosal pressure (ICP); PLATELET-RICH PLASMA; CAVERNOUS NERVE INJURY; MESENCHYMAL STEM-CELLS; ENDOTHELIAL PROGENITOR CELLS; EXTRACORPOREAL SHOCKWAVE THERAPY; MARROW STROMAL CELLS; GROWTH-FACTOR PDGF; RAT MODEL; GENE-THERAPY; CLINICAL-APPLICATIONS;

D O I：

10.3390/cells9051250

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Erectile dysfunction (ED) is an inability to attain or maintain adequate penile erection for successful vaginal intercourse, leading to sexual and relationship dissatisfaction. To combat ED, various surgical and non-surgical approaches have been developed in the past to restore erectile functions. These therapeutic interventions exhibit significant impact in providing relief to patients; however, due to their associated adverse effects and lack of long-term efficacy, newer modalities such as regenerative therapeutics have gained attention due to their safe and prolonged efficacy. Stem cells and platelet-derived biomaterials contained in platelet-rich plasma (PRP) are thriving as some of the major therapeutic regenerative agents. In recent years, various preclinical and clinical studies have evaluated the individual, as well as combined of stem cells and PRP to restore erectile function. Being rich in growth factors, chemokines, and angiogenic factors, both stem cells and PRP play a crucial role in regenerating nerve cells, myelination of axons, homing and migration of progenitor cells, and anti-fibrosis and anti-apoptosis of damaged cavernous nerve in corporal tissues. Further, platelet-derived biomaterials have been proven to be a biological supplement for enhancing the proliferative and differentiation potential of stem cells towards neurogenic fate. Therefore, this article comprehensively analyzes the progresses of these regenerative therapies for ED.

引用

页数：21