Structural glycobiology in the age of electron cryo-microscopy

被引：25
作者：
Atanasova, Mihaela [1 ]
Bagdonas, Haroldas [1 ]
Agirre, Jon [1 ]
机构：
[1] Univ York, Dept Chem, York Struct Biol Lab, York, N Yorkshire, England
来源：
CURRENT OPINION IN STRUCTURAL BIOLOGY | 2020年 / 62卷
基金：
英国工程与自然科学研究理事会;
关键词：
BUILDING MEANINGFUL MODELS; SYMBOL NOMENCLATURE; CARBOHYDRATE STRUCTURE; REFINEMENT; VISUALIZATION; REPRESENTATIONS; GLYCOPROTEINS; CONFORMATION; SOFTWARE; GLYCANS;
D O I：
10.1016/j.sbi.2019.12.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The methodology underpinning the construction, refinement, validation and analysis of atomic models of glycoproteins and protein-carbohydrate complexes has received a long-overdue boost in the last five years. This is a very timely development, as the resolution revolution in electron cryo-microscopy is now routinely delivering structures of key glycomedical importance, with a three-dimensional precision where X-ray crystallographic methods have traditionally floundered. This review will focus on the new software developments that have been introduced in the past two years, and their impact on the field of structural glycobiology in terms of published structures.
引用
收藏
页码：70 / 78
页数：9
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