Experimental validation of plugging during drop formation in a T-junction

被引:74
作者
Abate, Adam R. [1 ,2 ,3 ,4 ]
Mary, Pascaline [1 ,4 ]
van Steijn, Volkert [1 ,4 ]
Weitz, David A. [1 ,4 ]
机构
[1] Harvard Univ, Sch Engn & Appl Sci, Cambridge, MA 02138 USA
[2] Univ Calif San Francisco, Dept Bioengn & Therapeut Sci, San Francisco, CA 94143 USA
[3] Harvard Univ, Calif Inst Quantitat Biosci, Cambridge, MA 02138 USA
[4] Harvard Univ, Dept Phys, Cambridge, MA 02138 USA
基金
美国国家科学基金会;
关键词
RECTANGULAR MICROCHANNELS; MULTIPLE EMULSIONS; SOFT LITHOGRAPHY; MICROFLUIDICS; GENERATION; FLOW;
D O I
10.1039/c2lc21263c
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
At low capillary number, drop formation in a T-junction is dominated by interfacial effects: as the dispersed fluid flows into the drop maker nozzle, it blocks the path of the continuous fluid; this leads to a pressure rise in the continuous fluid that, in turn, squeezes on the dispersed fluid, inducing pinch-off of a drop. While the resulting drop volume predicted by this "squeezing'' mechanism has been validated for a range of systems, as of yet, the pressure rise responsible for the actual pinch-off has not been observed experimentally. This is due to the challenge of measuring the pressures in a T-junction with the requisite speed, accuracy, and localization. Here, we present an empirical study of the pressures in a T-junction during drop formation. Using Laplace sensors, pressure probes we have developed, we confirm the central ideas of the squeezing mechanism; however, we also uncover other findings, including that the pressure of the dispersed fluid is not constant but rather oscillates in anti-phase with that of the continuous fluid. In addition, even at the highest capillary number for which monodisperse drops can be formed, pressure oscillations persist, indicating that drop formation in confined geometries does not transition to an entirely shear-driven mechanism, but to a mechanism combining squeezing and shearing.
引用
收藏
页码:1516 / 1521
页数:6
相关论文
共 32 条
[1]   High-Order Multiple Emulsions Formed in Poly(dimethylsiloxane) Microfluidics [J].
Abate, A. R. ;
Weitz, D. A. .
SMALL, 2009, 5 (18) :2030-2032
[2]   Single-layer membrane valves for elastomeric microfluidic devices [J].
Abate, A. R. ;
Weitz, D. A. .
APPLIED PHYSICS LETTERS, 2008, 92 (24)
[3]   Faster multiple emulsification with drop splitting [J].
Abate, Adam R. ;
Weitz, David A. .
LAB ON A CHIP, 2011, 11 (11) :1911-1915
[4]   Synthesis of Monodisperse Microparticles from Non-Newtonian Polymer Solutions with Microfluidic Devices [J].
Abate, Adam R. ;
Kutsovsky, Mikhail ;
Seiffert, Sebastian ;
Windbergs, Maike ;
Pinto, Luis F. V. ;
Rotem, Assaf ;
Utada, Andrew S. ;
Weitz, David A. .
ADVANCED MATERIALS, 2011, 23 (15) :1757-+
[5]   High-speed microfluidic differential manometer for cellular-scale hydrodynamics [J].
Abkarian, M ;
Faivre, M ;
Stone, HA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (03) :538-542
[6]   Pressure drops for droplet flows in microfluidic channels [J].
Adzima, Brian J. ;
Velankar, Sachin S. .
JOURNAL OF MICROMECHANICS AND MICROENGINEERING, 2006, 16 (08) :1504-1510
[7]   Ultrahigh-throughput screening in drop-based microfluidics for directed evolution [J].
Agresti, Jeremy J. ;
Antipov, Eugene ;
Abate, Adam R. ;
Ahn, Keunho ;
Rowat, Amy C. ;
Baret, Jean-Christophe ;
Marquez, Manuel ;
Klibanov, Alexander M. ;
Griffiths, Andrew D. ;
Weitz, David A. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (09) :4004-4009
[8]   Formation of dispersions using "flow focusing" in microchannels [J].
Anna, SL ;
Bontoux, N ;
Stone, HA .
APPLIED PHYSICS LETTERS, 2003, 82 (03) :364-366
[9]   Droplet microfluidic technology for single-cell high-throughput screening [J].
Brouzes, Eric ;
Medkova, Martina ;
Savenelli, Neal ;
Marran, Dave ;
Twardowski, Mariusz ;
Hutchison, J. Brian ;
Rothberg, Jonathan M. ;
Link, Darren R. ;
Perrimon, Norbert ;
Samuels, Michael L. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (34) :14195-14200
[10]   Microfluidic methods for generating continuous droplet streams [J].
Christopher, G. F. ;
Anna, S. L. .
JOURNAL OF PHYSICS D-APPLIED PHYSICS, 2007, 40 (19) :R319-R336