A general and efficient method for the Suzuki-Miyaura coupling of 2-pyridyl nucleophiles

被引：207

作者：

Billingsley, Kelvin L. ^{[1
]}

Buchwald, Stephen L. ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 25期

关键词：

C-C coupling; nitrogen heterocycles; palladium; Suzuki-Miyaura coupling;

D O I：

10.1002/anie.200801465

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) One of the most general systems for the cross-coupling of aryl and heteroaryl bromides and chlorides with 2-pyridyl-derived nucleophiles has been developed, for which catalysts comprising [Pd2(dba)3] and either diaryl (1) or dialkyl phosphine oxide (2) supporting ligands were found to be ideal (see scheme). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

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页码：4695 / 4698

页数：4

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