Development and validation of language and visuospatial composite scores in ADNI

被引：49

作者：

Choi, Seo-Eun ^{[1
]}

Mukherjee, Shubhabrata ^{[1
]}

Gibbons, Laura E. ^{[1
]}

Sanders, R. Elizabeth ^{[1
]}

Jones, Richard N. ^{[2
]}

Tommet, Douglas ^{[2
]}

Mez, Jesse ^{[3
]}

Trittschuh, Emily H. ^{[4
,5
]}

Saykin, Andrew ^{[6
,7
]}

Lamar, Melissa ^{[8
,9
]}

Rabin, Laura ^{[10
]}

Foldi, Nancy S. ^{[11
]}

Sikkes, Sietske ^{[12
]}

Jutten, Roos J. ^{[12
]}

Grandoit, Evan ^{[13
]}

Mac Donald, Christine ^{[14
]}

Risacher, Shannon ^{[6
,7
]}

Groot, Colin ^{[12
]}

Ossenkoppele, Rik ^{[12
,15
]}

Initiative, Alzheimer's Disease Neuroimaging

Crane, Paul K. ^{[1
]}

机构：

[1] Univ Washington, Dept Med, Box 359780,325 Ninth Ave, Seattle, WA 98104 USA

[2] Brown Univ, Dept Neurol, Providence, RI 02912 USA

[3] Boston Univ, Dept Neurol, Boston, MA 02215 USA

[4] Univ Washington, Dept Psychiat, Seattle, WA 98104 USA

[5] VA Puget Sound Hlth Care Syst, Geriatr Res Educ & Clin Ctr, Puget Sound Vet Adm, Seattle, WA USA

[6] Indiana Univ, Dept Radiol, Indianapolis, IN 46204 USA

[7] Indiana Univ, Alzheimers Res Ctr, Indianapolis, IN 46204 USA

[8] Rush Univ, Rush Alzheimers Dis Ctr, Med Ctr, Chicago, IL 60612 USA

[9] Rush Univ, Dept Behav Sci & Psychiat, Med Ctr, Chicago, IL 60612 USA

[10] CUNY Brooklyn, Dept Psychol, New York, NY USA

[11] CUNY Queens Coll, Dept Psychol, New York, NY USA

[12] Vrije Univ Amsterdam Med Ctr, Alzheimer Ctr, Amsterdam UMC, Amsterdam, Netherlands

[13] Northwestern Univ, Dept Psychol, Evanston, IL USA

[14] Univ Washington, Dept Neurol Surg, Seattle, WA 98104 USA

[15] Lund Univ, Clin Memory Res Unit, Lund, Sweden

来源：

ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS | 2020年 / 6卷 / 01期

基金：

美国国家卫生研究院; 加拿大健康研究院;

关键词：

Alzheimer's Disease Neuroimaging Initiative; cognition; language; longitudinal analysis; magnetic resonance imaging; psychometrics; visuospatial functioning;

D O I：

10.1002/trc2.12072

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction: Composite scores may be useful to summarize overall language or visuospatial functioning in studies of older adults. Methods: We used item response theory to derive composite measures for language (ADNI-Lan) and visuospatial functioning (ADNI-VS) from the cognitive battery administered in the Alzheimer's Disease Neuroimaging Initiative (ADNI). We evaluated the scores among groups of people with normal cognition, mild cognitive impairment (MCI), and Alzheimer's disease (AD) in terms of responsiveness to change, association with imaging findings, and ability to differentiate between MCI participants who progressed to AD dementia and those who did not progress. Results: ADNI-Lan and ADNI-VS were able to detect changeover time and predict conversion from MCI to AD. They were associated with most of the pre-specified magnetic resonance imaging measures. ADNI-Lan had strong associations with a cerebrospinal fluid biomarker pattern. Discussion: ADNI-Lan and ADNI-VS may be useful composites for language and visuospatial functioning in ADNI.

引用

页数：13

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