Characterization of Three Novel HIV-1 Second-Generation Recombinants (CRF01_AE/CRF07_BC) Identified in Shenzhen, China

被引：1
作者：
Zhu, Bo [1 ,2 ]
Zhao, Jin [3 ]
Wang, Xiaorui [2 ]
Li, Hanping [2 ]
Liu, Yongjian [2 ]
Zheng, Chenli [3 ]
Jia, Lei [2 ]
Li, Tianyi [2 ]
Wang, Xiaolin [2 ]
Chen, Lin [3 ]
Li, Jingyun [2 ]
Zhang, Bohan [2 ]
Han, Jingwan [2 ]
Li, Lin [1 ,2 ]
机构：
[1] Anhui Med Univ, Sch Basic Med, Dept Microbiol, Hefei, Peoples R China
[2] Beijing Inst Microbiol & Epidemiol, Dept Virol, State Key Lab Pathogen & Biosecur, 20 Dongda St, Beijing 100071, Peoples R China
[3] Shenzhen Ctr Dis Control & Prevent, Shenzhen, Peoples R China
来源：
AIDS RESEARCH AND HUMAN RETROVIRUSES | 2022年 / 38卷 / 03期
基金：
中国国家自然科学基金;
关键词：
HIV; URF; SGR; recombinant; NFLG; INFECTIONS; CRF01-AE;
D O I：
10.1089/aid.2021.0211
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The prevalence of recombinant forms has greatly enhanced HIV-1 genetic diversity. Under co-circulation of major epidemic HIV-1 strains (CRF01_AE and CRF07_BC) in China, more CRF01_AE and CRF07_BC as the backbone of HIV-1 second-generation recombinants (SGRs) are also emerging. In this study, we identified three similar novel HIV-1 SGR strains composed of CRF01_AE and CRF07_BC from HIV-1 positive individuals in Shenzhen, China. Near full-length genome phylogenetic and recombinant analysis confirmed that these unique recombination forms were CRF01_AE and CRF07_BC strains recombined. Further subregion phylogenetic analysis indicated that all CRF01_AE fragments were from CRF01_AE cluster 4 prevalent among men who have sex with men, and all subtype B and C fragments derived from CRF07_BC. The emergence of novel recombinants of CRF01_AE/CRF07_BC indicates the increased genetic diversity of the HIV epidemic in Shenzhen. It is necessary to monitor HIV-1 SGR strains among high-risk populations for the epidemic dynamics of HIV-1 in Shenzhen, China.
引用
收藏
页码：242 / 247
页数：6
相关论文
共 10 条
[1]   The rapidly expanding CRF01_AE epidemic in China is driven by multiple lineages of HIV-1 viruses introduced in the 1990s [J].
Feng, Yi ;
He, Xiang ;
Hsi, Jenny H. ;
Li, Fan ;
Li, Xingguang ;
Wang, Quan ;
Ruan, Yuhua ;
Xing, Hui ;
Lam, Tommy Tsan-Yuk ;
Pybus, Oliver G. ;
Takebe, Yutaka ;
Shao, Yiming .
AIDS, 2013, 27 (11) :1793-1802
[2]   New Algorithms and Methods to Estimate Maximum-Likelihood Phylogenies: Assessing the Performance of PhyML 3.0 [J].
Guindon, Stephane ;
Dufayard, Jean-Francois ;
Lefort, Vincent ;
Anisimova, Maria ;
Hordijk, Wim ;
Gascuel, Olivier .
SYSTEMATIC BIOLOGY, 2010, 59 (03) :307-321
[3]   Genetic Characterization of 13 Subtype CRF01_AE Near Full-Length Genomes in Guangxi, China [J].
Li, Lin ;
Liang, Shujia ;
Chen, Lili ;
Liu, Wei ;
Li, Hanping ;
Liu, Yongjian ;
Bao, Zuoyi ;
Wang, Zheng ;
Zhuang, Daomin ;
Liu, Siyang ;
Li, Jingyun .
AIDS RESEARCH AND HUMAN RETROVIRUSES, 2010, 26 (06) :699-704
[4]  
Li XS, 2016, AIDS RES HUM RETROV, V32, P851, DOI [10.1089/aid.2016.0029, 10.1089/AID.2016.0029]
[5]   High Frequency of HIV-1 Dual Infections Among HIV-Positive Individuals in Cameroon, West Central Africa [J].
Powell, Rebecca L. R. ;
Urbanski, Mateusz M. ;
Burda, Sherri ;
Kinge, Thompson ;
Nyambi, Phillipe N. .
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2009, 50 (01) :84-92
[6]  
Shenzhen Statistical Bureau. Shenzhen China, 2020, SHENZH STAT YB
[7]  
Wu L, 2019, AIDS RES HUM RETROV, V35, P664, DOI [10.1089/aid.2019.0010, 10.1089/AID.2019.0010]
[8]  
Yao TC, 2020, AIDS RES HUM RETROV, V36, P527, DOI [10.1089/aid.2020.0002, 10.1089/AID.2020.0002]
[9]   Molecular surveillance of HIV-1 newly diagnosed infections in Shenzhen, China from 2011 to 2018 [J].
Zhang, Dong ;
Zheng, Chenli ;
Li, Hanping ;
Li, Hao ;
Liu, Yongjian ;
Wang, Xiaolin ;
Jia, Lei ;
Chen, Lin ;
Yang, Zhengrong ;
Gan, Yongxia ;
Zhong, Yifan ;
Han, Jingwan ;
Li, Tianyi ;
Li, Jingyun ;
Zhao, Jin ;
Li, Lin .
JOURNAL OF INFECTION, 2021, 83 (01) :76-83
[10]  
Zhou ZH, 2019, AIDS RES HUM RETROV, V35, P865, DOI [10.1089/AID.2019.0071, 10.1089/aid.2019.0071]
1