Sensorimotor demyelinating neuropathy with IgM antibody against gangliosides GD1a, GT1b and GM3

被引：5

作者：

Mizutani, K

Oka, N

Kusunoki, S

Kaji, R

Mezaki, T

Akiguchi, I

Shibasaki, H

机构：

[1] Kyoto Univ, Fac Med, Dept Neurol, Sakyo Ku, Kyoto 6068507, Japan

[2] Sakakibara Hakuho Hosp, Dept Neurol, Hisai, Japan

[3] Univ Tokyo, Sch Med, Dept Neurol, Tokyo 113, Japan

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 2001年 / 188卷 / 1-2期

关键词：

sensorimotor demyelinating neuropathy gangliosides; myelin-associated glycoprotein; antiganglioside antibodies;

D O I：

10.1016/S0022-510X(01)00537-8

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We report a patient with sensorimotor demyelinating neuropathy with high-titer IgM antibody against gangliosides GD1a, GT1b and GM3. The patient was a 65-year-old mate who was hospitalized with chief complaints of muscular weakness of all limbs and numbness of the hands and feet. Nerve-conduction studies revealed reduced conduction velocities of the motor nerves with increased temporal dispersion and loss of sensory nerve action potentials. Treatment with steroids was ineffective. IgM antibody against GD1a, GT1b and GM3, which are known to be the ligands for myelin-associated glycoprotein (MAG), might have played a role in the demyelination in this patient by inhibiting adhesion between myelin and axonal membrane. (C) 2001 Elsevier Science B.V. All rights reserved.

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页码：9 / 11

页数：3

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