Emerging non-invasive detection methodologies for lung cancer

被引：9

作者：

Li, Zhen ^{[1
,2
]}

Shu, Jinian ^{[2
]}

Yang, Bo ^{[2
]}

Zhang, Zuojian ^{[2
]}

Huang, Jingyun ^{[2
]}

Chen, Yang ^{[1
]}

机构：

[1] Chinese Acad Sci, Beijing Adv Sci & Innovat Ctr, 26 South Yanqi St, Beijing 101407, Peoples R China

[2] Univ Chinese Acad Sci, Natl Engn Lab VOCs Pollut Control Mat & Technol, Beijing 101408, Peoples R China

来源：

ONCOLOGY LETTERS | 2020年 / 19卷 / 05期

基金：

中国国家自然科学基金;

关键词：

lung cancer; non-invasive; detection; VOLATILE ORGANIC-COMPOUNDS; CIRCULATING TUMOR-CELLS; CHROMATOGRAPHY-MASS SPECTROMETRY; TYROSINE KINASE INHIBITORS; DNA METHYLATION; EXHALED BREATH; EGFR MUTATION; LIPID-PEROXIDATION; POTENTIAL MARKERS; EXOSOMAL PROTEINS;

D O I：

10.3892/ol.2020.11460

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The potential for non-invasive lung cancer (LC) diagnosis based on molecular, cellular and volatile biomarkers has been attracting increasing attention, with the development of advanced techniques and methodologies. It is standard practice to tailor the treatments of LC for certain specific genetic alterations, including the epidermal growth factor receptor, anaplastic lymphoma kinase and BRAF genes. Despite these advances, little is known about the internal mechanisms of different types of biomarkers and the involvement of their related biochemical pathways during the development of LC. The development of faster and more effective techniques is essential for the identification of different biomarkers. The present review summarizes some of the latest methods used for detecting molecular, cellular and volatile biomarkers in LC and their potential use in clinical diagnosis and targeted therapy.

引用

页码：3389 / 3399

页数：11

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