Understanding SARS-CoV-2-related multisystem inflammatory syndrome in children

被引：255

作者：

Rowley, Anne H. ^{[1
,2
,3
]}

机构：

[1] Northwestern Univ, Dept Pediat, Feinberg Sch Med, Chicago, IL 60611 USA

[2] Northwestern Univ, Dept Microbiol Immunol, Feinberg Sch Med, Chicago, IL 60611 USA

[3] Ann & Robert H Lurie Childrens Hosp Chicago, Chicago, IL 60611 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2020年 / 20卷 / 08期

关键词：

COVID-19; DISEASE;

D O I：

10.1038/s41577-020-0367-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A new multisystem inflammatory syndrome apparently related to infection with SARS-CoV-2 has recently been reported in older children (known as MIS-C), manifested by severe abdominal pain, cardiac dysfunction and shock. Here, I discuss the similarities and differences between MIS-C and Kawasaki disease, focusing on their epidemiology, aetiology and pathophysiological mechanisms.

引用

页码：453 / 454

页数：2

共 10 条

[1] Acute Heart Failure in Multisystem Inflammatory Syndrome in Children in the Context of Global SARS-CoV-2 Pandemic [J].

Belhadjer, Zahra ;

Meot, Mathilde ;

Bajolle, Fanny ;

Khraiche, Diala ;

Legendre, Antoine ;

Abakka, Samya ;

Auriau, Johanne ;

Grimaud, Marion ;

Oualha, Mehdi ;

Beghetti, Maurice ;

Wacker, Julie ;

Ovaert, Caroline ;

Hascoet, Sebastien ;

Selegny, Maelle ;

Malekzadeh-Milani, Sophie ;

Maltret, Alice ;

Bosser, Gilles ;

Giroux, Nathan ;

Bonnemains, Laurent ;

Bordet, Jeanne ;

Di Filippo, Sylvie ;

Mauran, Pierre ;

Falcon-Eicher, Sylvie ;

Thambo, Jean-Benoit ;

Lefort, Bruno ;

Moceri, Pamela ;

Houyel, Lucile ;

Renolleau, Sylvain ;

Bonnet, Damien .

CIRCULATION, 2020, 142 (05) :429-436

[2] Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19 [J].

Blanco-Melo, Daniel ;

Nilsson-Payant, Benjamin E. ;

Liu, Wen-Chun ;

Uhl, Skyler ;

Hoagland, Daisy ;

Moller, Rasmus ;

Jordan, Tristan X. ;

Oishi, Kohei ;

Panis, Maryline ;

Sachs, David ;

Wang, Taia T. ;

Schwartz, Robert E. ;

Lim, Jean K. ;

Albrecht, Randy A. ;

tenOever, Benjamin R. .

CELL, 2020, 181 (05) :1036-+

[3] Severe SARS-CoV-2 Infection in Children With Suspected Acute Abdomen: A Case Series From a Tertiary Hospital in Spain [J].

Cabrero-Hernandez, Marta ;

Garcia-Salido, Alberto ;

Leoz-Gordillo, Ines ;

Alonso-Cadenas, Jose Antonio ;

Gochi-Valdovinos, Ainhoa ;

Gonzalez Brabin, Anthony ;

De Lama Caro-Paton, Gema ;

Nieto-Moro, Montserrat ;

Martinez-de-Azagra-Garde, Amelia ;

Serrano-Gonzalez, Ana .

PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2020, 39 (08) :E195-E198

[4] Multisystem Inflammatory Syndrome in Children During the Coronavirus 2019 Pandemic: A Case Series [J].

Chiotos, Kathleen ;

Bassiri, Hamid ;

Behrens, Edward M. ;

Blatz, Allison M. ;

Chang, Joyce ;

Diorio, Caroline ;

Fitzgerald, Julie C. ;

Topjian, Alexis ;

John, Audrey R. Odom .

JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY, 2020, 9 (03) :393-398

[5] SARS-CoV-2 productively infects human gut enterocytes [J].

Lamers, Mart M. ;

Beumer, Joep ;

van der Vaart, Jelte ;

Knoops, Kevin ;

Puschhof, Jens ;

Breugem, Tim I. ;

Ravelli, Raimond B. G. ;

van Schayck, J. Paul ;

Mykytyn, Anna Z. ;

Duimel, Hans Q. ;

van Donselaar, Elly ;

Riesebosch, Samra ;

Kuijpers, Helma J. H. ;

Schipper, Debby ;

van de Wetering, Willine J. ;

de Graafl, Miranda ;

Koopmans, Marion ;

Cuppen, Edwin ;

Peters, Peter J. ;

Haagmans, Bart L. ;

Clevers, Hans .

SCIENCE, 2020, 369 (6499) :50-+

[6] Type I and Type III Interferons - Induction, Signaling, Evasion, and Application to Combat COVID-19 [J].

Park, Annsea ;

Iwasaki, Akiko .

CELL HOST & MICROBE, 2020, 27 (06) :870-878

[7] Hyperinflammatory shock in children during COVID-19 pandemic [J].

Riphagen, Shelley ;

Gomez, Xabier ;

Gonzalez-Martinez, Carmen ;

Wilkinson, Nick ;

Theocharis, Paraskevi .

LANCET, 2020, 395 (10237) :1607-1608

[8] A Protein Epitope Targeted by the Antibody Response to Kawasaki Disease [J].

Rowley, Anne H. ;

Baker, Susan C. ;

Arrollo, David ;

Gruen, Leah J. ;

Bodnar, Tetyana ;

Innocentini, Nancy ;

Hackbart, Matthew ;

Cruz-Pulido, Yazmin E. ;

Wylie, Kristine M. ;

Kim, Kwang-Youn A. ;

Shulman, Stanford T. .

JOURNAL OF INFECTIOUS DISEASES, 2020, 222 (01) :158-168

[9] An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study [J].

Verdoni, Lucio ;

Mazza, Angelo ;

Gervasoni, Annalisa ;

Martelli, Laura ;

Ruggeri, Maurizio ;

Ciuffreda, Matteo ;

Bonanomi, Ezio ;

D'Antiga, Lorenzo .

LANCET, 2020, 395 (10239) :1771-1778

[10] COVID-19 and Kawasaki disease in children [J].

Xu, Suowen ;

Chen, Mingwu ;

Weng, Jianping .

PHARMACOLOGICAL RESEARCH, 2020, 159

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