Tramadol in pregnancy and lactation

被引：39
作者：
Bloor, M. [1 ]
Paech, M. J. [1 ,2 ]
Kaye, R. [1 ]
机构：
[1] King Edward Mem Hosp Women, Dept Anaesthesia & Pain Med, Subiaco, WA 6008, Australia
[2] Univ Western Australia, Sch Med & Pharmacol, Nedlands, WA 6009, Australia
来源：
INTERNATIONAL JOURNAL OF OBSTETRIC ANESTHESIA | 2012年 / 21卷 / 02期
关键词：
Tramadol; Pregnancy; Lactation; Breastfeeding; Neonate; NEONATAL ABSTINENCE SYNDROME; DIFFERENT PHARMACOKINETICS; POSTMENSTRUAL AGE; CESAREAN DELIVERY; O-DEMETHYLATION; BREAST-MILK; LABOR PAIN; 1ST MONTHS; WITHDRAWAL; MOTHERS;
D O I：
10.1016/j.ijoa.2011.10.008
中图分类号：
R614 [麻醉学];
学科分类号：
100217 ;
摘要：
Tramadol produces analgesic effects through both non-opioid and weak opioid activity and is commonly used to treat mild to moderate pain. It has been in use for over 30 years and has a well-established safety profile in the general population. Since tramadol is not licensed for use in pregnancy and lactation, there is limited clinical research on its use in this patient population. A systematic review was undertaken of articles published in English before June 2011, searching Pubmed, Medline, CINAHL, Embase and Cochrane databases using the terms 'tramadol and pregnancy', 'tramadol and breastfeeding', 'tramadol and lactation', and 'tramadol and neonate'. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：163 / 167
页数：5
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