Development of Natural Product-Conjugated Metal Complexes as Cancer Therapies

被引：37

作者：

Ma, Dik-Lung ^{[1
]}

Wu, Chun ^{[1
]}

Cheng, Sha-Sha ^{[2
]}

Lee, Fu-Wa ^{[3
]}

Han, Quan-Bin ^{[4
]}

Leung, Chung-Hang ^{[2
]}

机构：

[1] Hong Kong Baptist Univ, Dept Chem, Kowloon, Hong Kong 999077, Peoples R China

[2] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Taipa 999078, Macao, Peoples R China

[3] Hong Kong Baptist Univ, Sch Continuing Educ, Coll Int Educ, Shek Mun, Hong Kong 999077, Peoples R China

[4] Hong Kong Baptist Univ, Sch Chinese Med, Kowloon, Hong Kong 999077, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 02期

基金：

中国国家自然科学基金;

关键词：

cancer therapy; transition metal complex; natural product; cytotoxicity; BIOLOGICAL-ACTIVITIES; IN-VIVO; INTERACTION INHIBITOR; ANTICANCER COMPLEXES; CURCUMIN; CISPLATIN; BINDING; FUTURE; DRUG; DNA;

D O I：

10.3390/ijms20020341

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Platinum-based drugs have revolutionized cancer care, but are unfortunately associated with various adverse effects. Meanwhile, natural product scaffolds exhibit multifarious bioactivities and serve as an attractive resource for cancer therapy development. Thus, the conjugation of natural product scaffolds to metal complexes becomes an attractive strategy to reduce the severe side effects arising from the use of metal bearing drugs. This review aims to highlight the recent examples of natural product-conjugated metal complexes as cancer therapies with enhanced selectivity and efficacy. We discuss the mechanisms and features of different conjugate complexes and present an outlook and perspective for the future of this field.

引用

页数：15

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