The discovery of ezetimibe: A view from outside the receptor

被引:263
作者
Clader, JW [1 ]
机构
[1] Schering Plough Res Inst, Cardiovasc & CNS Med Chem Dept, Kenilworth, NJ 07033 USA
关键词
D O I
10.1021/jm030283g
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
[No abstract available]
引用
收藏
页码:1 / 9
页数:9
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共 43 条
[1]   Effect of ezetimibe coadministered with atorvastatin in 628 patients with primary hypercholesterolemia - A prospective, randomized, double-blind trial [J].
Ballantyne, CM ;
Houri, J ;
Notarbartolo, A ;
Melani, L ;
Lipka, LJ ;
Suresh, R ;
Sun, S ;
LeBeaut, AP ;
Sager, PT ;
Veltri, EP .
CIRCULATION, 2003, 107 (19) :2409-2415
[2]   Ezetimibe [J].
Bays, H .
EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2002, 11 (11) :1587-1604
[3]   New lipid-modifying therapies [J].
Bruckert, E .
EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2003, 12 (03) :325-335
[4]   2-AZETIDINONES AS INHIBITORS OF CHOLESTEROL ABSORPTION [J].
BURNETT, DA ;
CAPLEN, MA ;
DAVIS, HR ;
BURRIER, RE ;
CLADER, JW .
JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (12) :1733-1736
[5]   ASYMMETRIC-SYNTHESIS AND ABSOLUTE STEREOCHEMISTRY OF CHOLESTEROL ABSORPTION INHIBITOR, SCH-48461 [J].
BURNETT, DA .
TETRAHEDRON LETTERS, 1994, 35 (40) :7339-7342
[6]  
BURNETT DA, IN PRESS CURR TOP ME
[7]   SUBSTITUTED (1,2-DIARYLETHYL)AMIDE ACYL-COA-CHOLESTEROL ACYLTRANSFERASE INHIBITORS - EFFECT OF POLAR GROUPS ON IN-VITRO AND IN-VIVO ACTIVITY [J].
CLADER, JW ;
BERGER, JG ;
BURRIER, RE ;
DAVIS, HR ;
DOMALSKI, M ;
DUGAR, S ;
KOGAN, TP ;
SALISBURY, B ;
VACCARO, W .
JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (10) :1600-1607
[8]   2-azetidinone cholesterol absorption inhibitors: Structure-activity relationships on the heterocyclic nucleus [J].
Clader, JW ;
Burnett, DA ;
Caplen, MA ;
Domalski, MS ;
Dugar, S ;
Vaccaro, W ;
Sher, R ;
Browne, ME ;
Zhao, HR ;
Burrier, RE ;
Salisbury, B ;
Davis, HR .
JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (19) :3684-3693
[9]   DESIGN OF POTENT COMPETITIVE INHIBITORS OF ANGIOTENSIN-CONVERTING ENZYME - CARBOXYALKANOYL AND MERCAPTOALKANOYL AMINO-ACIDS [J].
CUSHMAN, DW ;
CHEUNG, HS ;
SABO, EF ;
ONDETTI, MA .
BIOCHEMISTRY, 1977, 16 (25) :5484-5491
[10]   Ezetimibe [J].
Malcolm J. M. Darkes ;
Raewyn M. Poole ;
Karen L. Goa .
American Journal of Cardiovascular Drugs, 2003, 3 (1) :67-76