Intermolecular and intramolecular transamidation reactions

The amide functional group is resonance stabilised and direct reaction with amines is known to be difficult. Facile amide exchange reactions would enable the synthesis of important new amide based molecules, therefore transamidation reactions represent an important step in this direction. In order to ensure a transamidation reaction takes place, special requirements and conditions are required. According to the different structural characteristics of the carboxamide group and types of activation, the most relevant examples of this reaction will be reviewed.