Progress towards the total synthesis of tedanolide:: an efficient assembly of the C1-C11 subunit

被引：27

作者：

Loh, TP ^{[1
]}

Feng, LC ^{[1
]}

机构：

[1] Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 34期

关键词：

D O I：

10.1016/S0040-4039(01)01169-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The C-1-C-11 subunit of tedanolide was constructed using a boron-mediated syn aldol reaction as the key step to control the C-6 and C-7 stereocenters. Other features of this work include the asymmetric Sharpless dihydroxylation to incorporate the C-2, C-3 hydroxyl groups, selective protection of the hydroxyl group at C-2 as well as the usage of a tert-butyl ester to tolerate the attack of Grignard and enolate reagents. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：6001 / 6005

页数：5

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