β-carboline alkaloid suppresses NF-κB transcriptional activity through inhibition of IKK signaling pathway

被引:8
作者
Yoon, JW
Kang, JK
Lee, KR
Lee, HW
Han, JW
Seo, DW
Kim, YK
机构
[1] Sungkyunkwan Univ, Coll Pharm, Suwon 440746, South Korea
[2] NCI, Extracellular Matrix Pathol Sect, Pathol Lab, NIH, Bethesda, MD USA
[3] Kwandong Univ, Coll Med, Dept Pharmacol, Kangnung, South Korea
来源
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES | 2005年 / 68卷 / 23-24期
关键词
D O I
10.1080/15287390491009110
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Nuclear factor (NF)-kappa B transcription factors play an evolutionarily conserved and critical role in the triggering and coordination of both innate and adaptive immune responses. Therefore, there is intense interest in understanding the regulation of this transcription factor in the context of various diseases. Studies investigated the suppression mechanism of NF-kappa B signaling pathways by a beta-carboline alkaloid (C-1) in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. beta-Carboline alkaloid decreased the level of inducible nitric oxide sythase (iNOS) protein and NOS promoter activities in a concentration-dependent manner. This effect was accompanied by the reduction of NF-kappa B DNA binding activity as well as NF-kappa B nuclear translocation. In addition, beta-carboline alkaloid reduced the degradation and phosphorylation of I kappa B, and attenuated IKK activity in LPS-stimulated RAW 264.7 cells. Taken together, these results indicate that beta-carboline alkaloid has the capability to suppress NF-kappa B signaling pathway through inhibition of IKK activity in LPS-stimulated RAW 264.7 cells.
引用
收藏
页码:2005 / 2017
页数:13
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