Cadmium-induced time-dependent oxidative stress in liver of mice: a correlation with kidney

In the present investigation a time-responsive oxidative stress, both in liver and kidney were carried out following cadmium (Cd) exposure. Cadmium was administered subcutaneously on each other day in normal saline solution. Mice were sacrificed on the 15th, 30th and 45th days post-exposure. For oxidative stress study different biochemical markers, e.g. lipid peroxidation (LPO), reduced glutathione (GSH) and glutathione S-transferase (GST) activity were considered. Time-responsive exponential increase in the lipid peroxidation and decrease in glutathione level and glutathione S-transferase activity occurred both in hepatic and renal tissues following cadmium treatment. Though both the organs responded in a similar fashion, their magnitude of response was found to be different. Body weight did not differ but relative liver and kidney weight were found to be significantly increased at different time points. The possible mechanism of time-dependent cadmium-induced toxic effects and relation between hepatic and renal biochemical response have been discussed. (C) 1998 Elsevier Science B.V. All rights reserved.