Asymmetric synthesis of quinolizidine alkaloids (-)-lasubine I, (-)-lasubine II and (+)-subcosine II

被引：65

作者：

Chalard, P ^{[1
]}

Remuson, R ^{[1
]}

Gelas-Mialhe, Y ^{[1
]}

Gramain, JC ^{[1
]}

机构：

[1] Univ Blaise Pascal, Lab Chim Subst Nat, UMR 6504, F-63177 Aubiere, France

来源：

TETRAHEDRON-ASYMMETRY | 1998年 / 9卷 / 24期

关键词：

D O I：

10.1016/S0957-4166(98)00468-6

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The enantioselective synthesis of (-)-lasubine I 1 and the first asymmetric synthesis of (-)-lasubine II 2 and (+)-subcosine II 3 is described. The key step is the intramolecular cyclization of N-acyliminium ion 4 which is derived from (S)-aminoester 6. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：4361 / 4368

页数：8

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