FCGR3A V(176) polymorphism for systemic lupus erythematosus susceptibility in Mexican population

被引：6

作者：

Brambila-Tapia, Aniel J. L. ^{[2
]}

Gamez-Nava, Jorge I. ^{[6
]}

Gonzalez-Lopez, Laura ^{[5
]}

Sandoval-Ramirez, Lucila ^{[2
]}

Medina-Diaz, Julio ^{[2
]}

Maldonado, Montserrat ^{[3
]}

Gutierrez-Urena, Sergio R. ^{[4
]}

Martinez-Bonilla, Gloria ^{[4
]}

Martin-Marquez, Beatriz T. ^{[1
]}

Vazquez del Mercado, Monica ^{[1
]}

Nava-Zavala, Arnulfo ^{[6
]}

Munoz-Valle, Jose F. ^{[1
]}

Salazar-Paramo, Mario ^{[6
]}

Davalos-Rodriguez, Ingrid P. ^{[1
,2
]}

机构：

[1] Univ Guadalajara, CUCS, Unidad Invest Enfermedades Reumat & Musculoesquel, Guadalajara 44430, Jalisco, Mexico

[2] Ctr Invest Biomed Occidente CIBO, IMSS, Guadalajara, Jalisco, Mexico

[3] Hosp Civil Guadalajara Fray Antonio Alcalde, Div Mol Biol, Guadalajara, Jalisco, Mexico

[4] Hosp Civil Guadalajara Fray Antonio Alcalde, Serv Reumatol, Guadalajara, Jalisco, Mexico

[5] Hosp Gen Reg, Serv Reumatol, IMSS, Guadalajara, Jalisco, Mexico

[6] Unidad Invest Epidemiol Clin CMNO, IMSS, Guadalajara, Jalisco, Mexico

来源：

RHEUMATOLOGY INTERNATIONAL | 2011年 / 31卷 / 08期

关键词：

Systemic lupus erythematosus; FCGR3A V(176) polymorphism; RISK-FACTOR; ASSOCIATION; IIIA; NEPHRITIS; ALLELES; IIA;

D O I：

10.1007/s00296-010-1391-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The objective of this study is to establish whether there is an association between the presence of FCGR3A V(176) polymorphism with SLE or its manifestations. We included 94 patients according to the 1982 ACR criteria as well as 98 controls matched by age and gender. The 11 ACR diagnostic criteria were analyzed on the clinical files. The polymorphism FCGR3A V(176) was determined by direct sequencing. There was not an association between the polymorphism FCGR3A V(176) with SLE or its main manifestations. The allelic frequency for F(176) was: 0.80 and 0.72 in cases and controls, respectively (P = 0.09, IC95%: 0.42-1.07); and the genotypic frequency in the group of cases was: 0.65 for homozygotes F(176)/F(176), 0.30 for heterozygotes and 0.05 for the homozygotes V(176)/V(176), while for the control group it was 0.53, 0.39 and 0.08, respectively. The polymorphism FCGR3A V(176) is not associated with SLE or any of its manifestations in patients with SLE from the West of Mexico.

引用

页码：1065 / 1068

页数：4

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