Cellulose-SO3H: an efficient and biodegradable solid acid for the synthesis of quinazolin-4(1H)-ones

被引：73

作者：

Reddy, B. V. Subba ^{[1
]}

Venkateswarlu, A. ^{[1
]}

Madan, Ch ^{[1
]}

Vinu, A. ^{[2
,3
]}

机构：

[1] Indian Inst Chem Technol, Div Organ Chem, Hyderabad 500007, Andhra Pradesh, India

[2] Natl Inst Mat Sci, WPI Res Ctr, Int Ctr Mat Nanoarchitecton, Tsukuba, Ibaraki 3050044, Japan

[3] Indian Inst Chem Technol, NIMS IICT Mat Res Ctr, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON LETTERS | 2011年 / 52卷 / 16期

关键词：

Anthranilamide; Ketones; Aldehydes; Cellulose-SO3H; ONE-POT SYNTHESIS; ASYMMETRIC-SYNTHESIS; PRINS-CYCLIZATION; SULFURIC-ACID; DERIVATIVES; CATALYST; 2,3-DIHYDROQUINAZOLIN-4(1H)-ONES; QUINAZOLINONES; ALKALOIDS; 3H-QUINAZOLIN-4-ONES;

D O I：

10.1016/j.tetlet.2011.02.030

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The condensation of 2-aminobenzamide with aldehydes or ketones has been achieved using cellulosesulfonic acid under mild reaction conditions to furnish 2,3-dihydroquinazolin-4(1H)-ones in good yields with a high selectivity. The use of biodegradable solid acid catalyst, cellulosesulfonic acid makes this method quite simple, more convenient, and practical. This catalyst was also found to be very active for the synthesis of hydroxyalkylquinazolin-4-ones from cyclic enol ethers. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：1891 / 1894

页数：4

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