PKCβ regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1

被引：140
作者：
Shinohara, H
Yasuda, T
Aiba, Y
Sanjo, H
Hamadate, M
Watarai, H
Sakurai, H
Kurosaki, T [1 ]
机构：
[1] RIKEN, Res Ctr Allergy & Immunol, Lab Lymphocyte Differentiat, Tsurumi Ku, Kanagawa 2300045, Japan
[2] RIKEN, Lab Immune Regulat, Res Ctr Allergy & Immunol, Tsurumi Ku, Kanagawa 2300045, Japan
[3] Toyama Med & Pharmaceut Univ, Div Pathogen Biochem, Inst Nat Med, Toyama 9300194, Japan
来源：
JOURNAL OF EXPERIMENTAL MEDICINE | 2005年 / 202卷 / 10期
关键词：
D O I：
10.1084/jem.20051591
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The B cell antigen receptor (BCR)-mediated activation of I kappa B kinase (IKK) and nuclear factor kappa B require protein kinase C (PKC)beta; however, the mechanism by which PKC beta regulates IKK is unclear. Here, we demonstrate that another protein kinase, TGF beta-activated kinase (TAK)1, is essential for IKK activation in response to BCR stimulation. TAK1 interacts with the phosphorylated CARMA1 ( also known as caspase recruitment domain [CARD] 11, Bimp3) and this interaction is mediated by PKC beta. IKK is also recruited to the CARMA1-Bcl10-mucosal-associated lymphoid tissue 1 adaptor complex in a PKC beta-dependent manner. Hence, our data suggest that phosphorylation of CARMA1, mediated by PKC beta, brings two key protein kinases, TAK1 and IKK, into close proximity, thereby allowing TAK1 to phosphorylate IKK.
引用
收藏
页码：1423 / 1431
页数：9
相关论文
共 52 条
[11]   Identifying the MAGUK protein CARMA-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis [J].
Jun, JE ;
Wilson, LE ;
Vinuesa, CG ;
Lesage, S ;
Blery, M ;
Miosge, LA ;
Cook, MC ;
Kucharska, EM ;
Hara, H ;
Penninger, JM ;
Domashenz, H ;
Hong, NA ;
Glynne, RJ ;
Nelms, KA ;
Goodnow, CC .
IMMUNITY, 2003, 18 (06) :751-762
[12]   TAB2 and TAB3 activate the NF-κB pathway through binding to polyubiquitin chains [J].
Kanayama, A ;
Seth, RB ;
Sun, LJ ;
Ea, CK ;
Hong, M ;
Shaito, A ;
Chiu, YH ;
Deng, L ;
Chen, ZJ .
MOLECULAR CELL, 2004, 15 (04) :535-548
[13]   NF-κB at the crossroads of life and death [J].
Karin, M ;
Lin, A .
NATURE IMMUNOLOGY, 2002, 3 (03) :221-227
[14]   Phosphorylation meets ubiquitination:: The control of NF-κB activity [J].
Karin, M ;
Ben-Neriah, Y .
ANNUAL REVIEW OF IMMUNOLOGY, 2000, 18 :621-+
[15]   TAK1 mitogen-activated protein kinase kinase kinase is activated by autophosphorylation within its activation loop [J].
Kishimoto, K ;
Matsumoto, K ;
Ninomiya-Tsuji, J .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (10) :7359-7364
[16]   Regulation of B-cell signal transduction by adaptor proteins [J].
Kurosaki, T .
NATURE REVIEWS IMMUNOLOGY, 2002, 2 (05) :354-363
[17]   PDK1 nucleates T cell receptor-induced signaling complex for NF-κB activation [J].
Lee, KY ;
D'Acquisto, F ;
Hayden, MS ;
Shim, JH ;
Ghosh, S .
SCIENCE, 2005, 308 (5718) :114-118
[18]   NF-κB regulation in the immune system [J].
Li, QT ;
Verma, IM .
NATURE REVIEWS IMMUNOLOGY, 2002, 2 (10) :725-734
[19]   The roles of CARMA1, Bcl10, and MALT1 in antigen receptor signaling [J].
Lin, X ;
Wang, DM .
SEMINARS IN IMMUNOLOGY, 2004, 16 (06) :429-435
[20]   NF-κB-inducing kinase activates IKK-α by phosphorylation of Ser-176 [J].
Ling, L ;
Cao, ZD ;
Goeddel, DV .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (07) :3792-3797
123456