The hijacking of a receptor kinase-driven pathway by a wheat fungal pathogen leads to disease

被引：136

作者：

Shi, Gongjun ^{[1
]}

Zhang, Zengcui ^{[2
]}

Friesen, Timothy L. ^{[1
,2
]}

Raats, Dina ^{[3
,4
]}

Fahima, Tzion ^{[3
,4
]}

Brueggeman, Robert S. ^{[1
]}

Lu, Shunwen ^{[2
]}

Trick, Harold N. ^{[5
]}

Liu, Zhaohui ^{[1
]}

Chao, Wun ^{[6
]}

Frenkel, Zeev ^{[3
,4
]}

Xu, Steven S. ^{[2
]}

Rasmussen, Jack B. ^{[1
]}

Faris, Justin D. ^{[2
]}

机构：

[1] North Dakota State Univ, Dept Plant Pathol, Fargo, ND 58102 USA

[2] ARS, USDA, Cereal Crops Res Unit, Red River Valley Agr Res Ctr, Fargo, ND 58102 USA

[3] Univ Haifa, Inst Evolut, IL-3498838 Haifa, Israel

[4] Univ Haifa, Dept Evolutionary & Environm Biol, IL-3498838 Haifa, Israel

[5] Kansas State Univ, Dept Plant Pathol, Manhattan, KS 66506 USA

[6] ARS, USDA, Sunflower & Plant Biol Res Unit, Red River Valley Agr Res Ctr, Fargo, ND 58102 USA

来源：

SCIENCE ADVANCES | 2016年 / 2卷 / 10期

基金：

英国生物技术与生命科学研究理事会;

关键词：

RESISTANCE; PROTEIN; TOXA; SUSCEPTIBILITY; INFECTION; EFFECTOR; REVEALS; SYSTEM; GENES; 1BS;

D O I：

10.1126/sciadv.1600822

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Necrotrophic pathogens live and feed on dying tissue, but their interactions with plants are not well understood compared to biotrophic pathogens. The wheat Snn1 gene confers susceptibility to strains of the necrotrophic pathogen Parastagonospora nodorum that produce the SnTox1 protein. We report the positional cloning of Snn1, a member of the wall-associated kinase class of receptors, which are known to drive pathways for biotrophic pathogen resistance. Recognition of SnTox1 by Snn1 activates programmed cell death, which allows this necrotroph to gain nutrients and sporulate. These results demonstrate that necrotrophic pathogens such as P. nodorum hijack host molecular pathways that are typically involved in resistance to biotrophic pathogens, revealing the complex nature of susceptibility and resistance in necrotrophic and biotrophic pathogen interactions with plants.

引用

页数：9

共 36 条

[1] Tsn1-Mediated Host Responses to ToxA from Pyrenophora tritici-repentis
Adhikari, Tika B.
Bai, Jianfa
Meinhardt, Steven W.
Gurung, Suraj
Myrfield, Mary
Patel, Jaimin
Ali, Shaukat
Gudmestad, Neil C.
Rasmussen, Jack B.
[J]. MOLECULAR PLANT-MICROBE INTERACTIONS, 2009, 22 (09) : 1056 - 1068
[2] Greenhouse and field testing of transgenic wheat plants stably expressing genes for thaumatin-like protein, chitinase and glucanase against Fusarium graminearum
Anand, A
Zhou, T
Trick, HN
Gill, BS
Bockus, WW
Muthukrishnan, S
[J]. JOURNAL OF EXPERIMENTAL BOTANY, 2003, 54 (384) : 1101 - 1111
[3] Defence Responses of Arabidopsis thaliana to Infection by Pseudomonas syringae Are Regulated by the Circadian Clock
Bhardwaj, Vaibhav
Meier, Stuart
Petersen, Lindsay N.
Ingle, Robert A.
Roden, Laura C.
[J]. PLOS ONE, 2011, 6 (10):
[4] A domain swap approach reveals a role of the plant wall-associated kinase 1 (WAK1) as a receptor of oligogalacturonides
Brutus, Alexandre
Sicilia, Francesca
Macone, Alberto
Cervone, Felice
De Lorenzo, Giulia
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (20) : 9452 - 9457
[5] Ubiquitin promoter-based vectors for high-level expression of selectable and/or screenable marker genes in monocotyledonous plants
Christensen, AH
Quail, PH
[J]. TRANSGENIC RESEARCH, 1996, 5 (03) : 213 - 218
[6] Genetic analysis of disease susceptibility contributed by the compatible Tsn1-SnToxA and Snn1-SnTox1 interactions in the wheat-Stagonospora nodorum pathosystem
Chu, C. -G.
Faris, J. D.
Xu, S. S.
Friesen, Timothy L.
[J]. THEORETICAL AND APPLIED GENETICS, 2010, 120 (07) : 1451 - 1459
[7] Stable resistance to Wheat streak mosaic virus in wheat mediated by RNAi
Cruz, Luisa F.
Rupp, Jessica L. Shoup
Trick, Harold N.
Fellers, John P.
[J]. IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-PLANT, 2014, 50 (06) : 665 - 672
[8] Engineering plant resistance by constructing chimeric receptors that recognize damage-associated molecular patterns (DAMPs)
De Lorenzo, Giulia
Brutus, Alexandre
Savatin, Daniel Valentin
Sicilia, Francesca
Cervone, Felice
[J]. FEBS LETTERS, 2011, 585 (11) : 1521 - 1528
[9] Plant immunity: towards an integrated view of plant-pathogen interactions
Dodds, Peter N.
Rathjen, John P.
[J]. NATURE REVIEWS GENETICS, 2010, 11 (08) : 539 - 548
[10] MUSCLE: multiple sequence alignment with high accuracy and high throughput
Edgar, RC
[J]. NUCLEIC ACIDS RESEARCH, 2004, 32 (05) : 1792 - 1797

← 1 2 3 4 →