Co-occurrence of ADHD and low IQ has genetic origins

被引：195
作者：
Kuntsi, J
Eley, TC
Taylor, A
Hughes, C
Asherson, P
Caspi, A
Moffitt, TE
机构：
[1] Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Ctr, London SE5 8AF, England
[2] Univ Cambridge, Ctr Family Res, Cambridge, England
来源：
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS | 2004年 / 124B卷 / 01期
关键词：
attention deficit hyperactivity disorder (ADHD); hyperactivity; intelligence quotient (IQ); genetics; twin study;
D O I：
10.1002/ajmg.b.20076
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Previous studies show that the symptoms of attention deficit hyperactivity disorder (ADHD) and lower intelligence quotient (IQ) covary in children. We investigated the aetiology of this association in a large population-based sample of 5-year-old twins. The twins were individually assessed on an IQ test, and data on ADHD symptoms were obtained from mother interviews and teacher ratings. Confirming previous studies, the phenotypic correlation between ADHD symptom scores and IQ was -0.3 and, in a categorical analysis, children with a Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) ADHD research diagnosis obtained IQ scores nine points lower, on average, than comparison children. We show here that the co-occurrence of ADHD and lower IQ has genetic origins: 86% of the association between ADHD symptom scores and IQ, and 100% of the association between ADHD diagnosis and IQ, was accounted for by genetic influences that are shared by ADHD and IQ. Some candidate genes for ADHD could also contribute to variation in IQ or vice versa. (C) 2003 Wiley-Liss, Inc.
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页码：41 / 47
页数：7
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